予防健診部
研究活動の概要

循環器病克服のために最も必要とされる予防を行う為には循環器病の発症に関する要因を明らかにすること、その要因に関して予防法を開発し行うことが必要である。

予防健診部では主に、吹田研究から多くのエビデンスとして貢献してきた。また、禁煙外来により循環器疾患の一次予防、再発予防に努めてきた。また、日本で唯一の脂質基準分析室を大阪府からセンターに移管し、その運営をおこなってきた。

平成26年度は、これまでの成果を踏まえ、健診・事後指導の拡充、吹田研究からの多くのエビデンスの創出、包括的な喫煙対策への取り組み、脂質標準化事業の推進をおこなった。

2014年の主な研究成果

吹田研究において、コホート研究として、血圧と高コレステロール血症と循環器疾患との関係を明らかにし1、さらに、日本人の10年間の心筋梗塞発症リスクスコアを開発し、吹田スコアとして発表した2。

  1. Tsukinoki R, Okamura T, Watanabe M, Kokubo Y, Higashiyama A, Nishimura K, Takegami M, Murakami Y, Okayama A, Miyamoto Y. Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita study. Am J of Hypertens. 2014;27(11):1362-9.
  2. Nishimura K, Okamura T, Watanabe M, Nakai M, Takegami M, Higashiyama A, Kokubo Y, Okayama A, Miyamoto Y. Predicting coronary heart disease using risk factor categories for a Japanese urban population, and comparison with the framingham risk score: the suita study. J Atheroscler Thromb. 2014;21(8):784-98.
研究業績
  1. Iwasaki Y, Suganami T, Hachiya R, Shirakawa I, Kim-Saijo M, Tanaka M, Hamaguchi M, Takai-Igarashi T, Nakai M, Miyamoto Y and Ogawa Y. Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Diabetes. 63, 152-161, 2014.
  2. Iwashima Y, Kokubo Y, Ono T, Yoshimuta Y, Kida M, Kosaka T, Maeda Y, Kawano Y and Miyamoto Y. Additive Interaction of Oral Health Disorders on Risk of Hypertension in a Japanese Urban Population: The Suita Study. American Journal of Hypertension. 27, 710-719, 2014.
  3. Tsukinoki R, Okamura T, Watanabe M, Kokubo Y, Higashiyama A, Nishimura K, Takegami M, Murakami Y, Okayama A and Miyamoto Y. Blood Pressure, Low-Density Lipoprotein Cholesterol, and Incidences of Coronary Artery Disease and Ischemic Stroke in Japanese: The Suita Study. American Journal of Hypertension. 27, 1362-1369, 2014.
  4. Kataoka Y, Yasuda S, Miyamoto Y, Sase K, Kosuge M, Kimura K, Yoshimasa Y and Miyazaki S. Clinical Predictors of Atheroma Progression Despite Optimal Glycemic Control in Early-Stage Diabetic Patients with Coronary Artery Disease: Insight from the DIANA Study. Journal of Atherosclerosis and Thrombosis. 21, 509-518, 2014.
  5. Nakai M, Chen D, Nishimura K and Miyamoto Y. Comparative Study of Four Methods in Missing Value Imputations under Missing Completely at Random Mechanism. Open Journal of Statistics. 4, 27-37, 2014.
  6. Kamitani S, Nishimura K, Nakamura F, Kada A, Nakagawara J, Toyoda K, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Matsuda S, Miyamoto Y, Iwata M, Suzuki A, Ishikawa KB, Kataoka H, Morita K, Kobayashi Y and Iihara K. Consciousness level and off-hour admission affect discharge outcome of acute stroke patients: a J-ASPECT study. Journal of the American Heart Association. 3, e001059 -, 2014.
  7. Miyamoto Y. Could Glucose Management After Acute Myocardial Infarction Cure Myocardial Damage?. Circulation Journal . 78, 67-68, 2014.
  8. Nishimura K, Nakamura F, Takegami M, Fukuhara S, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Miyachi S, Nagata I, Toyoda K, Matsuda S, Kataoka H, Miyamoto Y, Kitaoka K, Kada A and Iihara K. Cross-Sectional Survey of Workload and Burnout Among Japanese Physicians Working in Stroke Care The Nationwide Survey of Acute Stroke Care Capacity for Proper Designation of Comprehensive Stroke Center in Japan (J-ASPECT) Study. Circulation:Cardiovascular Quality and Outcomes. 7, 414-422, 2014.
  9. Inohara T, Kohsaka S, Okamura T, Watanabe M, Nakamura Y, Higashiyama A, Kadota A, Okuda N, Murakami Y, Ohkubo T, Miura K, Okayama A and Ueshima H. Cumulative impact of axial, structural, and repolarization ECG findings on long-term cardiovascular mortality among healthy individuals in Japan: National Integrated Project for Prospective Observation of Non-Communicable Disease and its Trends in the Aged, 1980 and 1990. European Journal of Preventive Cardiology. 21, 1501-1508, 2014.
  10. Iihara K, Nishimura K, Kada A, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Toyoda K, Matsuda S, Miyamoto Y, Suzuki A, Ishikawa KB, Kataoka H, Nakamura F and Kamitani S. Effects of Comprehensive Stroke Care Capabilities on In-Hospital Mortality of Patients with Ischemic and Hemorrhagic Stroke: J-ASPECT Study. PLOS ONE. 9, , 2014.
  11. Kokubo Y. Epidemiology of transient ischemic attack. Frontiers of Neurology and Neuroscience . 1, 69-81, 2014.
  12. Murray CJL, Ortblad KF, Kokubo Y and al. et. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet . 384, 1005-1070, 2014.
  13. Kassebaum NJ, Bertozzi-Villa A, Kokubo Y and al. et. Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet . 384, 980-1004, 2014.
  14. Wang HD, Liddell CA, Coates, Kokubo Y and al. et. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet . 384, 957-979, 2014.
  15. Ng M, Fleming T, Kokubo Y and al. et. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet . 384, 766-781, 2014.
  16. Yokoyama S, Ueshima H, Miida T, Nakamura M, Takata K, Fukukawa T, Goto T, Harada-Shiba M, Sano M, Kato K and Matsuda K. High-Density Lipoprotein Levels Have Markedly Increased Over the Past Twenty Years in Japan. Journal of Atherosclerosis and Thrombosis. 21, 151-160, 2014.
  17. Noguchi T, Kawasaki T, Tanaka A, Yasuda S, Goto Y, Ishihara M, Nishimura K, Miyamoto Y, Node K and Koga N. High-Intensity Signals in Coronary Plaques on Noncontrast T1-Weighted Magnetic Resonance Imaging as a Novel Determinant of Coronary Events. Journal of the American College of Cardiology. 63, 989-999, 2014.
  18. Mizuhashi S, Kataoka H, Sano N, Ideguchi M, Higashi M, Miyamoto Y and Iihara K. Impact of diabetes mellitus on characteristics of carotid plaques and outcomes after carotid endarterectomy. Acta Neurochirurgica. 156, 927-933, 2014.
  19. Nakamura M, Kayamori Y, Iso H, Kitamura A, Kiyama M, Koyama I, Nishimura K, Nakai M, Noda H, Dasti M, Vesper HW and Miyamoto Y. LDL cholesterol performance of beta quantification reference measurement procedure. Clinica Chimica Acta. 431, 288-293, 2014.
  20. Eshak ES, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Sawada N, Inoue M and Tsugane S. Modification of the Excess Risk of Coronary Heart Disease Due to Smoking by Seafood/Fish Intake. American Journal of Epidemiology. 179, 1173-1181, 2014.
  21. Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kaab S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ and George AL. Novel Calmodulin Mutations Associated With Congenital Arrhythmia Susceptibility. Circulation:Cardiovascular Genetics. 7, 466-474, 2014.
  22. Nishimura K, Okamura T, Watanabe M, Nakai M, Takegami M, Higashiyama A, Kokubo Y, Okayama A and Miyamoto Y. Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the Framingham Risk Score: The Suita Study. Journal of Atherosclerosis and Thrombosis. 21, 784-798, 2014.
  23. Minakata K, Bando K, Tanaka S, Takanashi S, Konishi H, Miyamoto Y, Ueshima K, Yasuno S, Ueda Y, Okita Y, Masuda I, Okabayashi H, Yaku H, Okamura Y, Tanemoto K, Arinaga K, Hisashi Y and Sakata R. Preoperative Chronic Kidney Disease as a Strong Predictor of Postoperative Infection and Mortality After Coronary Artery Bypass Grafting. Circulation Journal. 78, 2225-2231, 2014.
  24. Kokubo Y. Prevention of hypertension and cardiovascular diseases: a comparison of lifestyle factors in Westerners and East Asians. Hypertension. 63, 655-660, 2014.
  25. Nagai Y, Kohriyama T, Origasa H, Minematsu K, Yokota C, Uchiyama S, Ibayashi S, Terayama Y, Takagi M, Kitagawa K, Nomura E, Hosomi N, Ohtsuki T, Yamawaki T, Matsubara Y, Nakamura M, Yamasaki Y, Mori E, Fukushima M, Kobayashi S, Shinohara Y, Yamaguchi T and Matsumoto M. Rationale, design, and baseline features of a randomized controlled trial to assess the effects of statin for the secondary prevention of stroke: the Japan Statin Treatment Against Recurrent Stroke (J-STARS). International Journal of Stroke. 9, 232-239, 2014.
  26. Eshak ES, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Sawada N, Inoue M and Tsugane S. Rice consumption is not associated with risk of cardiovascular disease morbidity or mortality in Japanese men and women: a large population-based, prospective cohort study. The American Journal of Clinical Nutrition. 100, 199-207, 2014.
  27. Sugiyama D, Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Kawamura K, Kuwabara K, Nishimura K, Kadota A, Nishida Y, Hirata T, Imano H, Miyamatsu N, Miyamoto Y, Sawamura T and Okamura T. Risk of Hypercholesterolemia in Patients with Cardiovascular Disease and the Population Attributable Fraction in a 24-year Japanese Cohort Study. Journal of Atherosclerosis and Thrombosis. e-pub, , 2014.
  28. Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, Yamamoto M, Watanabe M, Amano A, Maeda Y and Miyamoto Y. Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: The Suita study. Atherosclerosis. 237, 123-128, 2014.
  29. Sakamoto Y, Kokubo Y, Toyoda K, Watanabe M, Tanigawa T and Miyamoto Y. Sleep-disordered breathing is associated with elevated human atrial natriuretic peptide levels in a Japanese urban population: the Suita study. International Journal of Cardiology. 173, 334-335, 2014.
  30. Kosaka T, Ono T, Yoshimuta Y, Kida M, Kikui M, Nokubi T, Maeda YO, Kokubo Y, Watanabe M and Miyamoto Y. The effect of periodontal status and occlusal support on masticatory performance: the Suita study. Journal of Clinical Periodontology. 41, 497-503, 2014.
  31. Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ishimitsu T, Ito M, Ito S, Itoh H, Iwao H, Kai H, Kario K, Kashihara N, Kawano Y, Kim-Mitsuyama S, Kimura G, Kohara K, Komuro I, Kumagai H, Matsuura H, Miura K, Morishita R, Naruse M, Node K, Ohya Y, Rakugi H, Saito I, Saitoh S, Shimada K, Shimosawa T, Suzuki H, Tamura K, Tanahashi N, Tsuchihashi T, Uchiyama M, Ueda S, Umemura S, Maemura K, Okada K, Katayama S, Tsuchihashi T, Hisatome I, Arai H, Itoh H, Suzuki H, Minakami H, Matsumoto M, Ogawa Y, Ueda S, Ouchi Y, Itakura H, Ito S, Abe I, Akishita M, Adachi K, Arita M, Arima S, Ando S, Ikeda S, Iso H, Ichihara A, Ito T, Imai E, Iwashima Y, Uehara Y, Uchiyama S, Umemoto S, Ura N, Urata H, Eguch i K, Ohishi M, Okubo I, Ohkubo T, Okura T, Okamura T, Ogawa H, Kashiwagi A, Katsuya T, Kato N, Kamide K, Kawashima Y, Kikuchi T, Kitazono T, Kitamura K, Kimura K, Kihara Y, Kiyohara Y, Kusaka M, Kushiro T, Kohno M, Kobayashi S, Goto A, Kokubo Y, Saito Y, Shibata H, Sasamura H, Shimohama S, Suzuki Y, Takazawa K, Takahashi S, Takahashi H, Takeda K, Takeda Y, Tsutsui H, Tsubakihara Y, Doi Y, Tomiyama H, Tomino Y, Toyoda K, Narita I, Nishikawa T, Hayashi K, Hirata Y, Hirawa N, Hirooka Y, Fukuda N, Horio T, Hoshide S, Makino H, Masuzaki H, Matsumura K, Miura S, Miura T, Mukoyama M, Murashima A, Murohara T, Morimoto S, Yamakage M, Yamashina A, Yoshimura M, Watanabe T, Abe K, Arakawa K, Iimura O, Omae T, Kaneko Y, Hiwada K, Fukiyama K, Yazaki Y, Eto T, Ogihara, Kikuchi K, Saruta T, Takishita S, Matsuoka H, Shimizu H, Yamaguchi I, Mikami H, Yamamoto W, Nakao M, Mori H and Saitoh S. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertension Research . 37, 253-390, 2014.
  32. Sugiyama D, Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Kawamura K, Kuwabara K, Nishimura K, Kadota A, Nishida Y, Hirata T, Imano H, Miyamatsu N, Miyamoto Y, Sawamura T and Okamura T. The Relationship between Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B and the Cardio-Ankle Vascular Index in Healthy Community Inhabitants: The KOBE Study. Journal of Atherosclerosis and Thrombosis . e-pub, , 2014.
  33. Miida T, Nishimura K, Okamura T, Hirayama S, Ohmura H, Yoshida H, Miyashita Y, Ai M, Tanaka A, Sumino H, Murakami M, Inoue I, Kayamori Y, Nakamura M, Nobori T, Miyazawa Y, Teramoto T and Yokoyama S. Validation of homogeneous assays for HDL-cholesterol using fresh samples from healthy and diseased subjects. Atherosclerosis. 233, 253-259, 2014.
  34. Yokoyama Y, Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A, Okamura T and Miyamoto Y. Vegetarian Diets and Blood Pressure A Meta-analysis. JAMA Internal Medicine . 174, 577-587, 2014.
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