国立循環器病研究センター研究所

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組織・各部の紹介 血管生理学部

高谷 智英

氏名 高谷 智英 NoPhoto
よみ たかや ともひで
所属・職務 血管生理学部 流動研究員
内線番号 2371
FAX番号 06-6835-5329
Eメール takaya@ri.ncvc.go.jp
専門 循環器病学
主要論文・著書 論文
  • Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, and Hasegawa K; Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. J Cell Physiol, 226:248-254, 2011.
  • Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, and Kimura T; MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes. Mol Cell Biol, 31:744-755, 2011.
  • Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, and Hasegawa K; Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts. Circ J, 74:723-729, 2010.
  • Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, and Heike T; Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. Cardiovasc Res, 88:314-323, 2010.
  • Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, and Hasegawa K; Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. J Biol Chem, 285:9566-9568, 2010.
  • Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Horie T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, and Hasegawa K; Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice. Biochem Biophys Res Commun, 398:576-580, 2010.
  • Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, and Hasegawa K; MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells. Circ J, 73:1492-1497, 2009.
  • Takaya T, Kawamura T, Morimoto T, Ono K, Kita T, Shimatsu A, and Hasegawa K; Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes. J Biol Chem, 283:9828-9835, 2008.
  • Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, and Hasegawa K; The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest, 118:868-878, 2008.
  • Wada H, Abe M, Ono K, Morimoto T, Kawamura T, Takaya T, Satoh N, Fujita M, Kita T, Shimatsu A, and Hasegawa K; Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. Biochem Biophys Res Commun, 374:731-736, 2008.
  • Takanabe R, Ono K, Abe Y, Takaya T, Horie T, Wada H, Kita T, Satoh N, Shimatsu A, Hasegawa K; Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem Biophys Res Commun, 376:728-732, 2008.
  • Morimoto T, Fujita M, Kawamura T, Sunagawa Y, Takaya T, Wada H, Shimatsu A, Kita T, and Hasegawa K; Myocardial regulation of p300 and p53 by doxorubicin involves ubiquitin pathways. Circ J, 72:1506-1511, 2008.
  • Hosseinkhani M, Hasegawa K, Ono K, Kawamura T, Takaya T, Morimoto T, Wada H, Shimatsu A, Prat SG, Suemori H, Nakatsuji N, and Kita T; Trichostatin A induces myocardial differentiation of monkey ES cells. Biochem Biophys Res Commun, 356:386-391, 2007.
受賞

学位 博士(医学)
所属学会 日本循環器学会、日本心不全学会、日本臨床分子医学会
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最終更新日 2011年07月12日

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国立循環器病研究センター研究所:〒565-8565 大阪府吹田市藤白台5丁目7番1号 電話:06-6833-5012(代)
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