ホーム > 各部のご紹介 > 細胞生物学部 > Li-Kun Phng

細胞生物学部

スタッフ紹介 [Li-Kun Phng]

氏名 Li-Kun Phng
NoPhoto
よみ
所属・職務 細胞生物学部 research fellow
内線番号 1234
FAX番号 06-6835-5461
Eメール likun.phng@ncvc.go.jp
棟/部屋番号 研究所本館6階 616
専門 Research on mechanisms regulating endothelial cell dynamics and blood vessel morphogenesis during sprouting angiogenesis.
主要論文・著書 論文
  1. Phng LK, Gebala V, Bentley K, Philippides A, Wacker A, Mathivet T, Sauteur L, Stanchi S, HG Belting, Affolter M, Gerhardt H. Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization. DEVELOPMENTAL CELL (2015).
  2. Phng LK, Stanchi F and Gerhardt H. Filopodia are dispensable for endothelial tip cell guidance. DEVELOPMENT 140, 4031-4040 (2013).
  3. De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquiere B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P. Role of PFKFB3-driven glycolysis in vessel sprouting. CELL 154, 651-663 (2013).
  4. Guarani V, Deflorian G, Franco CA, Kruger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. NATURE 473, 234-238 (2011).
  5. Phng LK, Potente M, Leslie JD, Babbage J, Nyqvist D, Lobov I, Ondr JK, Rao S, Lang RA, Thurston G, Gerhardt H. Nrarp coordinates endothelial Notch and Wnt signalling to control vessel density in angiogenesis. DEVELOPMENTAL CELL 16, 70-82 (2009).
  6. Paye JMD, Phng LK, Lanahan AA, Gerhardt H and Simons M. Synectin-dependent regulation of arterial maturation. DEVELOPMENTAL DYNAMICS 238, 604-610 (2009).
  7. Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B. Angiogenesis selectively requires the p110a isoform of PI3-kinase to control endothelial cell migration. NATURE 453, 662-666 (2008).
  8. Worsley AG, LeibundGut-Landmann S, Slack E, Phng LK, Gerhardt H, Reis e Sousa C, MacDonald AS. Dendritic cell expression of the Notch ligand Jagged2 is not essential for Th2 response induction in vivo. EURUPEAN JOURNAL OF IMMUNOLOGY 38, 1043-1049 (2008).
  9. Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalen M, Gerhardt H, Betsholtz C. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. NATURE 445, 776-780 (2007).
受賞
  1. 2014 - present. Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship.
  2. 2010 - 2013. Human Frontier Science Program (HFSP) long-term fellowship.
  3. 2009 - 2010. EMBO long-term fellowship.
  4. 2009. Awarded the European Molecular Biology Laboratory (EMBL) Interdisciplinary Postdocs (EIPOD) fellowship (not used).
  5. 2009. European Molecular Biology Organization (EMBO) short-term fellowship.
  6. 2004 -2009. Cancer Research UK Graduate Studentship.
学位 博士(医学) University College London, UK
所属学会 日本動物学会、日本比較内分泌学会、Society for Integrative and Comparative Biology (USA)
教育活動
その他の活動
研究者情報
リンク

最終更新日 2015年04月01日

ページ上部へ