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心臓再生制御部

業績

心臓再生制御部ではゼブラフィッシュ・マウスを用いた心筋細胞の脱分化と増殖制御機構の研究や透明魚を用いたイメージング研究など、広く心臓の発生と再生に関する基礎研究を推進しています。最近では企業との共同研究も開始し、新たな心臓の再生医療の開発を目指す応用研究も進めています。

主要な論文一覧

菊地部長

  1. Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Hiroyuki Nakajima, Hiroyuki Ishikawa, Takuya Yamamoto, Ayano Chiba, Hajime Fukui, Keisuke Sako, Moe Fukumoto, Kenny Mattonet, Hyouk-Bum Kwon, Subhra P Hui, Gergana D Dobreva, Kazu Kikuchi, Christian SM Helker, Didier YR Stainier, Naoki Mochizuki. Dev Cell (doi: 10.1016/j.devcel.2022.12.013) (2023)
  2. Zebrafish: An emerging model to study the cellular dynamics of inflammation in development, regeneration, and disease. C Sullivan, S de Oliveira, K Kikuchi, BL King. Front Cell Dev Biol 10:1102381 (2023)
  3. Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Subhra P. Hui*, Kotaro Sugimoto, Delicia Z. Sheng, Kazu Kikuchi*. (*Corresponding author) Front Immunol 13:981000 (2022)
  4. Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection. Julia Y. Kam, Elinor Hortle, Elizabeth Krogman, Sherridan E. Warner, Kathryn Wright, Kaiming Luo, Tina Cheng, Pradeep Manuneedhi Cholan, Kazu Kikuchi, James A. Triccas, Warwick J. Britton, Matt D. Johansen, Laurent Kremer, Stefan H. Oehlers. Nat Commun 13:952 (2022)
  5. Zebrafish heme oxygenase 1a is necessary for normal development and macrophage migration. Kaiming Luo, Masahito Ogawa, Anita Ayer, Warwick J. Britton, Roland Stocker, Kazu Kikuchi, Stefan H. Oehlers. Zebrafish 19:7-17 (2022)
  6. Haeme oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish. Kaiming Luo, Roland Stocker, Warwick J. Britton, Kazu Kikuchi, Stefan H. Oehlers. FEBS Lett 289:671-81 (2022)
  7. Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Percival P. D’Gama, Tao Qiu, Mehmet I. Cosacak, Dheeraj Rayamajhi, Ahsen Konac, Jan N. Hansen, Christa Ringers, Francisca Acuña-Hinrichsen, Subhra P. Hui, Emilie W. Olstad, Yan L. Chong, Charlton K. A. Lim, Astha Gupta, Chee P. Ng, Benedikt Nilges, Nachiket D. Kashikar, Dagmar Wachten, David Liebl, Kazu Kikuchi, Caghan Kizil, Emre Yaksi, Sudipto Roy*, Nathalie Jurisch-Yaksi*. (*Contributed equally) Cell Rep 37:109775 (2021)
  8. Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish. Ogawa M, Geng FS, Humphreys DT, Kristianto E, Sheng DZ, Hui SP, Zhang Y, Sugimoto K, Nakayama M, Zheng D, Hesselson D, Hodson MP, Bogdanovic O, Kikuchi KScience 372:201-5 (2021)
  9. Deep conservation of the enhancer regulatory code in animals. Emily S. Wong*, Dawei Zheng†, Siew Z. Tan†, Neil L. Bower, Victoria Garside, Gilles Vanwalleghem, Federico Gaiti, Ethan Scott, Benjamin M. Hogan, Kazu Kikuchi, Edwina McGlinn, Mathias Francois*‡, Bernard M. Degnan*‡. (*Corresponding author; †, ‡Contributed equally) Science 370:eaax8137 (2020)
  10. Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling. Catherine R. Cochrane, Vijesh Vaghjiani, Anette Szczepny, W. Samantha N. Jayasekara, Alvaro Gonzalez-Rajal, Kazu Kikuchi, Geoffrey W. McCaughan, Andrew Burgess, Daniel J. Gough, D. Neil Watkins, Jason E. Cain. J Clin Invest 130:4006-18 (2020)
  11. New function of zebrafish regulatory T cells in organ regeneration. Kazu Kikuchi. Curr Opin Immunol 63:7-13 (2020)
  12. Pharmacological enhancement of regeneration-dependent regulatory T cell recruitment in zebrafish. Stephanie F. Zwi, Clarisse Choron, Dawei Zheng, David Nguyen, Yuxi Zhang, Camilla Roshal, Kazu Kikuchi*, Daniel Hesselson*. (*Corresponding author) Int J Mol Sci 20:5189 (2019)
  13. Comparative regenerative mechanisms across different mammalian tissues. Siiri E. Iismaa, Xenia Kaidonis, Amy M. Nicks, Nikolay Bogush, Kazu Kikuchi, Nawazish Naqvi, Richard P. Harvey, Ahsan Husain, Robert M. Graham. NPJ Regen Med 3:6 (2018)
  14. Zebrafish regulatory T cells mediate organ-specific regenerative programs. Hui SP, Sheng DZ, Sugimoto K, Gonzalez-Rajal A, Nakagawa S, Hesselson D, Kikuchi KDev Cell 43:659-672 (2017)
  15. Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch. Sugimoto K, Hui SP, Sheng DZ, Kikuchi KeLife 6: e24635 (2017)
  16. NAD deficiency, congenital malformations, and niacin supplementation. Hongjun Shi, Annabelle Enriquez, Melissa Rapadas, Ella M. M. A. Martin, Roni Wang, Julie Moreau, Chai K. Lim, Justin O. Szot, Eddie Ip, James N. Hughes, Kotaro Sugimoto, David T. Humphreys, Aideen M. McInerney-Leo, Paul J. Leo, Ghassan J. Maghzal, Jake Halliday, Janine Smith, Alison Colley, Paul R. Mark, Felicity Collins, David O. Sillence, David S. Winlaw, Joshua W. K. Ho, Gilles J. Guillemin, Matthew A. Brown, Kazu Kikuchi, Paul Q. Thomas, Roland Stocker, Eleni Giannoulatou, Gavin Chapman, Emma L. Duncan, Duncan B. Sparrow, Sally L. Dunwoodie. N Engl J Med 377:544-552 (2017)
  17. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Kotaro Sugimoto, Subhra P. Hui, Delicia Z. Sheng, Alvaro Gonzalez-Rajal, Maki Nakayama, Kazu KikuchiDev Comp Immunol 73:156-62 (2017)
  18. Endogenous mechanisms of cardiac regeneration. Michelle S. W. Xiang, Kazu Kikuchi. Int Rev Cell Mol Biol 326:67-131 (2016)
  19. Myocardial NF-kB activation is essential for zebrafish heart regeneration. Ravi Karra, Anne K. Knecht, Kazu Kikuchi, Kenneth D. Poss. Proc Natl Acad Sci USA 112:13255-13260 (2015)
  20. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Gregory Nachtrab, Kazu Kikuchi, Valerie A. Tornini, Kenneth D. Poss. Development 140:3754-3764 (2013)
  21. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Yi Fang, Vikas Gupta, Ravi Karra, Jennifer E. Holdway, Kazu Kikuchi, Kenneth D. Poss. Proc Natl Acad Sci USA 110:13416-13421 (2013)
  22. Dedifferentiation, transdifferentiation, and proliferation: mechanisms underlying cardiac regeneration in zebrafish. Kazu Kikuchi. Curr Pathobiol Rep 3:81-88 (2015)
  23. Advances in understanding the mechanism of zebrafish heart regeneration. Kazu Kikuchi. Stem Cell Res 13:542-555 (2014)
  24. Zebrafish second heart field development relies on ALPM progenitor specification and nkx2.5 function. Burcu Guner-Ataman, Noelle Paffett-Lugassy, Meghan S. Adams, Kathleen R. Nevis, Leila Jahangiri, Pablo Obregon, Kazu Kikuchi, Kenneth D. Poss, Caroline E. Burns, C. Geoffrey Burns. Development 140:1353-1363 (2013)
  25. Cardiac regenerative capacity and mechanisms. Kazu Kikuchi*, Kenneth D. Poss*. (*Corresponding author) Annu Rev Cell Dev Biol 28:719-741 (2012)
  26. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Jinhu Wang, Daniela Panáková, Kazu Kikuchi, Jennifer E. Holdway, Matthew Gemberling, James S. Burris, Sumeet Pal Singh, Amy L. Dickson, Yi-Fan Lin, M. Khaled Sabeh, Andreas A. Werdich, Deborah Yelon, Calum A. Macrae, Kenneth D. Poss. Development 138:3421-3430 (2011)
  27. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Kazu Kikuchi, Vikas Gupta, Jinhu Wang, Jennifer E. Holdway, Airon A. Wills, Yi Fang, Kenneth D. Poss. Development 138:2895-2902 (2011)
  28. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Kazu Kikuchi, Jennifer E. Holdway, Robert J. Major, Nicola Blum, Randall D. Dahn, Gerrit Begemann, Kenneth D. Poss. Dev Cell 20:397-404 (2011)
  29. A dual role for ErbB2 signaling in cardiac trabeculation. Jiandong Liu, Michael Bressan, David Hassel, Jan Huisken, David Staudt, Kazu Kikuchi, Kenneth D. Poss, Takashi Mikawa, Didier Y. R. Stainier. Development 137:3867-3875 (2010)
  30. Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Chunyue Yin, Kazu Kikuchi, Tatiana Hochgreb, Kenneth D. Poss, Didier Y. R. Stainier. Dev Cell 18:973-984 (2010)
  31. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Kazu Kikuchi, Jennifer E. Holdway, Andreas A. Werdich, Ryan M. Anderson, Yi Fang, Gregory F. Egnaczyk, Todd Evans, Calum A. Macrae, Didier Y. R. Stainier, Kenneth D Poss. Nature 464:601-605 (2010)
  32. IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression. Kazu Kikuchi, Hirotake Kasai, Akiko Watanabe, Anne Y. Lai, Motonari Kondo. J Immunol 181:383-392 (2008)
  33. Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment. Chia-Lin Hsu, Kazu Kikuchi, Motonari Kondo. Blood 110:1420-1428 (2007)
  34. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Alexandra Lepilina*, Ashley N. Coon*, Kazu Kikuchi, Jennifer E. Holdway, Richard W. Roberts, C. Geoffrey Burns, Kenneth D. Poss (*Contributed equally) Cell 127:607-619 (2006)
  35. Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth. Kazu Kikuchi, Motonari Kondo. Proc Natl Acad Sci USA 103:17852-17857 (2006)
  36. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. Kazu Kikuchi, Anne Y Lai, Chia-Lin Hsu, Motonari Kondo. J Exp Med 201: 1197-1203 (2005)

渡邉室長

  1. Harada Y, Tanaka T, Arai Y, Isomoto Y, Nakano A, Nakao S, Urasaki A, Watanabe Y, Kawamura T, Nakagawa O. ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development. Genes Cells 26(8):611-626 (2021)
  2. Kinugasa-Katayama Y, Watanabe Y, Hisamitsu T, Arima Y, Liu NM, Tomimatsu A, Harada Y, Arai Y, Urasaki A, Kawamura T, Saito Y, Nakagawa O. Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation. Genesis 59(4):e23416 (2021)
  3. Seya D, Ihara D, Shirai M, Kawamura T, Watanabe Y*, Nakagawa O*. (*Co-corresponding authors). A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis. Dev Growth Differ 63(1):82-92 (2021)
  4. Watanabe Y *, Seya D, Ihara D, Ishii S, Uemoto T, Kubo A, Arai Y, Isomoto Y, Nakano A, Abe T, Shigeta M, Kawamura T, Saito Y, Ogura T, Nakagawa O*. (*Co-corresponding authors). Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription. J Biol Chem 295:17632-17645 (2020)
  5. Ihara D, Watanabe Y *, Seya D, Arai Y, Isomoto Y, Nakano A, Kubo A, Ogura T, Kawamura T, Nakagawa O*. (*Co-corresponding authors). Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors. Dev Biol 461:124-131 (2020)
  6. Miyoshi T, Hisamitsu T, Ishibashi-Ueda H, Ikemura K, Ikeda T, Miyazato M, Kangawa K, Watanabe Y, Nakagawa O, Hosoda H. Maternal administration of tadalafil improves fetal ventricular systolic function in a Hey2 knockout mouse model of fetal heart failure. Int J Cardiol 302:110-116. (2020)
  7. Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y, Nakagawa O. Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells. Angiogenesis 21(2):415-423 (2018)
  8. Watanabe Y, Miyasaka KY, Kubo A, Kida YS, Nakagawa O, Hirate Y, Sasaki H, Ogura T. Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Sci Rep 7:46135 (2017)
  9. Fujita M, Sakabe M, Ioka T, Watanabe Y, Kinugasa-Katayama Y, Tsuchihashi T, Utset MF, Yamagishi H, Nakagawa O. Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev 139:65-73 (2016)
  10. Inoue S, Moriya M, Watanabe Y, Miyagawa-Tomita S, Niihori T, Oba D, Ono M, Kure S, Ogura T, Matsubara Y, Aoki Y. New BRAF knock-in mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet 23(24):6553-66 (2014)
  11. Vincent SD, Mayeuf-Louchart A, Watanabe Y, Brzezinski JA 4th, Miyagawa-Tomita S, Kelly RG, Buckingham M. Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet 23(19):5087-101 (2014)
  12. Huynen L, Suzuki T, Ogura T, Watanabe Y, Millar CD, Hofreiter M, Smith C, Mirmoeini S, Lambert DM. Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes). BMC Evol Biol 14:75 (2014)
  13. Aoki Y, Niihori T, Banjo T, Okamoto N, Mizuno S, Kurosawa K, Ogata T, Takada F, Yano M, Ando T, Hoshika T, Barnett C, Ohashi H, Kawame H, Hasegawa T, Okutani T, Nagashima T, Hasegawa S, Funayama R, Nagashima T, Nakayama K, Inoue S, Watanabe Y, Ogura T, Matsubara Y. Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome. Am J Hum Genet 93(1):173-80 (2013)
  14. Watanabe Y, Zaffran S, Kuroiwa A, Higuchi H, Ogura T, Harvey RP, Kelly RG, Buckingham M. Fgf10 regulation in the second heart field by Tbx1, Nkx2-5 and Islet1 reveals a genetic switch for down-regulation of transcription in the myocardium. Proc Natl Acad Sci U S A 109:18273-18280 (2012)
  15. Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham M. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res 106:495-503 (2010)
  16. Watanabe Y, Buckingham M. The formation of the embryonic mouse heart: heart fields and myocardial cell lineages. Ann N Y Acad Sci 1188:15-24 (2010)
  17. Suzuki K, Machiyama F, Nishino S, Watanabe Y, Kashiwagi K, Kashiwagi A, Yoshizato K. Molecular features of thyroid hormone-regulated skin remodeling in Xenopus laevis during metamorphosis. Dev Growth Differ 51(4):411-27 (2009)
  18. Park EJ*, Watanabe Y *, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM. (*Co-first authors). An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development 135:3599-3610 (2008)
  19. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128(5):947-59 (2007)
  20. Watanabe Y *, Kokubo H*, Miyagawa-Tomita S, Endo M, Igarashi K, Aisaki K, Kanno J, Saga Y. (*Co-first authors). Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development 133:1625-1634 (2006)
  21. Utoh R, Shigenaga S, Watanabe Y, Yoshizato K. Platelet-derived growth factor signaling as a cue of the epithelial-mesenchymal interaction required for anuran skin metamorphosis. Dev Dyn 227(2):157-69 (2003)
  22. Watanabe Y, Tanaka R, Kobayashi H, Utoh R, Suzuki K, Obara M, Yoshizato K. Metamorphosis-dependent transcriptional regulation of xak-c, a novel Xenopus type I keratin gene. Dev Dyn 225(4):561-70 (2002)
  23. Oofusa K, Tooi O, Kashiwagi A, Kashiwagi K, Kondo Y, Watanabe Y, Sawada T, Fujikawa K, Yoshizato K. Expression of thyroid hormone receptor beta A gene assayed by transgenic Xenopus laevis carrying its promoter sequences. Mol Cell Endocrinol 181(1-2):97-110 (2001)
  24. Watanabe Y*, Kobayashi H*, Suzuki K, Kotani K, Yoshizato K. (*Co-first authors). New epidermal keratin genes from Xenopus laevis: hormonal and regional regulation of their expression during anuran skin metamorphosis. Biochim Biophys Acta 1517(3):339-50 (2001)

安藤室長

  1. Ando K*., Tong L., Peng D., Vázquez-Liébanas E., Chiyoda H., He L., Liu J., Kawakami K., Mochizuki N., Fukuhara S., Grutzendler J., Betsholtz C*. (*Corresponding author) KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling. Cell. Jun 6;57(11):1383-1399.e7. DOI: https://doi.org/10.1016/j.devcel.2022.04.019. (2022)
  2. Peng D., Ando K*, Gloger M., Skoczylas R., Mochizuki N., Betsholtz C., Fukuhara S., Koltowska K*. (*Corresponding author). Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells. eLife. doi: https://doi.org/10.7554/eLife.74094. (2022)
  3. Ando K*, Ishii T., Fukuhara S. (*Corresponding author). Zebrafish Vascular Mural Cell Biology: Recent Advances, Development, and Functions', Life. 11: 1041. Doi. doi.org/10.3390/life11101041. (2021)
  4. Yamamoto K., Takagi Y., Ando K., Fukuhara S. Rap1 small GTPase regulates vascular endothelial-cadherin-mediated endothelial cell-cell junctions and vascular permeability. Pharm. Bull. 44(10):1371-1379. doi: 10.1248/bpb.b21-00504. (2021)
  5. Ando K*, Shih H., Ebarasi L., Grosse A., Portman D., Chiba A., Mattonet K., Gerrif C., Stainier D.Y.R., Mochizuki N., Fukuhara S., Betsholtz C., Lawson N.D*. (*Corresponding author). Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development. Dev. Biol. Nov. Vol(479), 11-22. Doi: https://doi.org/10.1016/j.ydbio.2021.06.010. (2021)
  6. Rho S. Oguri-Nakamura E., Ando K. Yamamoto K., Takagi Y., Fukuhara S. Protocol for analysis of integrin-mediated cell adhesion of lateral plate mesoderm cells isolated from zebrafish embryos. STAR Protocols. 2(2), doi:10.1016/j.xpro.2021.100428. (2021)
  7. Rho SS, Kobayashi I, Oguri-Nakamura E, Ando K, Fujiwara M, Kamimura N, Hirata H, Iida A, Iwai Y, Mochizuki N, Fukuhara S. Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Dev Cell. Jun 3;49(5):681-696.e6. (2019)
  8. Castro M, Laviña B, Ando K, Álvarez-Aznar A, Abu Taha A, Brakebusch C, Dejana E, Betsholtz C, Gaengel K. CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Circ. Res. Apr 12;124(8):1240-1252. (2019)
  9. Ando K*, Wang W, Peng D, Chiba A, Lagendijk A, Barske L, Crup JG, Stainier DYR, Lendahl U, Koltowska K, Hogan BM, Fukuhara S, Mochizuki N, Betsholtz C. (Corresponding author). Periarterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling. Development. Jan 25;146(2). (2019)
  10. Noishiki C, Yuge S, Ando K, Wakayama Y, Mochizuki N, Ogawa R, Fukuhara1 S. Live imaging of angiogenesis during cutaneous wound healing in adult zebrafish. May;22(2):341-354. (2019)
  11. He L, Vanlandewijck M, Mäe MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Gouveia L, Sun Y, Raschperger E, Segerstolpe Å, Liu J, Gustafsson S, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C. Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types. Sci Data. Aug 21;5:180160. (2018)
  12. Vanlandewijck M, He L, Andaloussi Mäe M, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Leonor Gouveia L, Raschperger E, Räsänen M, Zarb Y, Mochizuki N,   Keller A, Lendahl U, Betsholtz C. A Molecular Atlas of Cell Types and Zonation in the Nature. 554:475–480. (2018)
  13. Rho SS, Ando K, Fukuhara S. Dynamic Regulation of Vascular Permeability by Vascular Endothelial Cadherin-Mediated Endothelial Cell-Cell Junctions. Nippon Med. Sch. 84(4):148-159. (2017)
  14. Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Fukuhara S, Mochizuki N, Ishii S, Kishima H, Takakura N. Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact. Cell Rep. 20(9):2072- (2017)
  15. Miura K, Nojiri T, Akitake Y, Ando K, Fukuhara S, Zenitani M, Kimura T, Hino J, Miyazato M, Hosoda H, Kangawa K. CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading. Biochem J. 474(11):1897-1918. (2017)
  16. Nakajima H, Yamamoto K, Agarwala S, Terai K, Fukui H, Fukuhara S, Ando K, Miyazaki T, Yokota Y, Schmelzer E, Belting HG, Affolter M, Lecaudey V, Mochizuki N. Flow-Dependent   Endothelial YAP Regulation Contributes to Vessel Maintenance. Cell. 40(6):523-536. (2017)
  17. Wild R, Klems A, Takamiya M, Hayashi Y, Strähle U, Ando K, Mochizuki N, van Impel A, Schulte-Merker S, Krueger J, Preau L, le Noble F. Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Commun. 8: 13991 (2017)
  18. Ando K, Fukuhara S, Izumi N, Nakajima H, Fukui H, Kelsh RN, Mochizuki N. Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish. Development. 143(8):1328- (2016)
  19. He L, Vanlandewijck M, Raschperger E, Andaloussi Mäe M, Jung B, Lebouvier T, Ando K, Hofmann J, Keller A, Betsholtz C. Analysis of the brain mural cell transcriptome. Rep. 6:35108. (2016)
  20. Fukuhara S, Fukui H, Wakayama Y, Ando K, Nakajima H, Mochizuki N. Looking back and moving forward: Recent advances in understanding of cardiovascular development by imaging of zebrafish. Growth Differ. 4:333-340. (2015)
  21. Mikelis C, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams R, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Commun. 6: 6725. (2015)
  22. Kashiwada T, Fukuhara S, Terai K, Tanaka T, Wakayama Y, Ando K, Nakajima H, Fukui H, Yuge S, Saito. Y, Gemma A, Mochizuki N. β-Catenin-dependent transcription is central to Bmp-mediated formation of venous vessels. 142, 497-509. (2015)
  23. Wakayama Y, Fukuhara S, Ando K, Matsuda M, Mochizuki N. Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. Cell. 32:109-122. (2015)
  24. Fukuhara S, Zhang J, Yuge S, Ando K, Wakayama Y, Sakaue-Sawano A, Miyawaki A, Mochizuki N. Visualizing the cell-cycle progression of endothelial cells in zebrafish. Biol. 393: 10-23. (2014)
  25. Ando K, Fukuhara S, Moriya T, Obara Y, Nakahata N, Mochizuki N. Rap1potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. J. Cell Biol. 202: 901-916. (2013)
  26. Kwon HB, Fukuhara S, Asakawa K, Ando K, Kashiwada T, Kawakami K, Hibi M, Kwon YG, Kim KW, Alitalo K, Mochizuki N. The parallel growth of motoneuron axons with the dorsalaorta depends on Vegfc/Vegfr3 signaling in zebrafish. 140:4081-4090. (2013)
  27. Ando K, Obara Y, Sugama J, Kotani A, Koike N, Ohkubo S, Nakahata N. P2Y2 receptor Gq/11 signaling at lipid rafts is required for UTP-induced cell migration in NG 108-15 cells. Pharmacol. Exp. Ther. 334:809-819. (2010)

最終更新日:2023年02月08日

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