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病態代謝部

スタッフ紹介 [斯波 真理子]

氏名 斯波 真理子
斯波 真理子 写真
よみ しば まりこ
所属・職務 病態代謝部 部長
内線番号 8209
FAX番号 06-6872-8415
Eメール mshiba★ncvc.go.jp      ★は@
棟/部屋番号
専門 脂質代謝、分子生物学
主要論文・著書 論文
  • Yamamoto, T., Yahara, A., Waki, R., Yasuhara, H., Wada, F., Harada-Shiba, M., and Obika, S. 2015. Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo. Org Biomol Chem 13:3757-3765.
  • Pang, J., Sullivan, D.R., Harada-Shiba, M., Ding, P.Y., Selvey, S., Ali, S., and Watts, G.F. 2015. Significant gaps in awareness of familial hypercholesterolemia among physicians in selected Asia-Pacific countries: A pilot study. J Clin Lipidol 9:42-48.
  • Hori, M., Ishihara, M., Yuasa, Y., Makino, H., Yanagi, K., Tamanaha, T., Kishimoto, I., Kujiraoka, T., Hattori, H., and Harada-Shiba, M. 2015. Removal of plasma mature and furin-cleaved proprotein convertase subtilisin/kexin 9 by low-density lipoprotein-apheresis in familial hypercholesterolemia: development and application of a new assay for PCSK9. J Clin Endocrinol Metab 100:E41-49.
  • Yamamoto, T., Fujii, N., Yasuhara, H., Wada, S., Wada, F., Shigesada, N., Harada-Shiba, M., and Obika, S. 2014. Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice. Nucleic Acid Ther 24:283-290.
  • Tachibana, Y., Munisso, M.C., Kamata, W., Kitagawa, M., Harada-Shiba, M., and Yamaoka, T. 2014. Quick nuclear transportation of siRNA and in vivo hepatic ApoB gene silencing with galactose-bearing polymeric carrier. J Biotechnol 175:15-21.
  • Yuasa, Y., Osaki, T., Makino, H., Iwamoto, N., Kishimoto, I., Usami, M., Minamino, N., and Harada-Shiba, M. 2014. Proteomic analysis of proteins eliminated by low-density lipoprotein apheresis. Ther Apher Dial 18:93-102.
  • Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S., Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. 2014. Familial hypercholesterolemia. J Atheroscler Thromb 21:6-10.
  • Yamamoto, T., Obika, S., Nakatani, M., Yasuhara, H., Wada, F., Shibata, E., Shibata, M.A., and Harada-Shiba, M. 2014. Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma. Eur J Pharmacol 723:353-359.
  • Yokoyama, S., Ueshima, H., Miida, T., Nakamura, M., Takata, K., Fukukawa, T., Goto, T., Harada-Shiba, M., Sano, M., Kato, K., et al. 2014. High-density lipoprotein levels have markedly increased over the past twenty years in Japan. J Atheroscler Thromb 21:151-160.
  • Harada-Shiba, M., Arai, H., Oikawa, S., Ohta, T., Okada, T., Okamura, T., Nohara, A., Bujo, H., Yokote, K., Wakatsuki, A., et al. 2012. Guidelines for the management of familial hypercholesterolemia. J Atheroscler Thromb 19:1043-1060.
  • Harada-Shiba, M., Arai, H., Okamura, T., Yokote, K., Oikawa, S., Nohara, A., Okada, T., Ohta, T., Bujo, H., Watanabe, M., et al. 2012. Multicenter study to determine the diagnosis criteria of heterozygous familial hypercholesterolemia in Japan. J Atheroscler Thromb 19:1019-1026.
  • Yamamoto, T., Yasuhara, H., Wada, F., Harada-Shiba, M., Imanishi, T., and Obika, S. 2012. Superior Silencing by 2',4'-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors. J Nucleic Acids 2012:707323.
  • Kang, J.H., Tachibana, Y., Obika, S., Harada-Shiba, M., and Yamaoka, T. 2012. Efficient reduction of serum cholesterol by combining a liver-targeted gene delivery system with chemically modified apolipoprotein B siRNA. J Control Release 163:119-124.
  • Uchida, S., Itaka, K., Chen, Q., Osada, K., Ishii, T., Shibata, M.A., Harada-Shiba, M., and Kataoka, K. 2012. PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses. Mol Ther 20:1196-1203.
  • Sugisawa, T., Okamura, T., Makino, H., Watanabe, M., Kishimoto, I., Miyamoto, Y., Iwamoto, N., Yamamoto, A., Yokoyama, S., and Harada-Shiba, M. 2012. Defining patients at extremely high risk for coronary artery disease in heterozygous familial hypercholesterolemia. J Atheroscler Thromb 19:369-375.
  • Yokoyama, S., Yamashita, S., Ishibashi, S., Sone, H., Oikawa, S., Shirai, K., Ohta, T., Bujo, H., Kobayashi, J., Arai, H., et al. 2012. Background to discuss guidelines for control of plasma HDL-cholesterol in Japan. J Atheroscler Thromb 19:207-212.
  • Arai, H., Ishibashi, S., Bujo, H., Hayashi, T., Yokoyama, S., Oikawa, S., Kobayashi, J., Shirai, K., Ota, T., Yamashita, S., et al. 2012. Management of type IIb dyslipidemia. J Atheroscler Thromb 19:105-114.
  • Gotoda, T., Shirai, K., Ohta, T., Kobayashi, J., Yokoyama, S., Oikawa, S., Bujo, H., Ishibashi, S., Arai, H., Yamashita, S., et al. 2012. Diagnosis and management of type I and type V hyperlipoproteinemia. J Atheroscler Thromb 19:1-12.
  • Uchida, S., Itaka, K., Chen, Q., Osada, K., Miyata, K., Ishii, T., Harada-Shiba, M., and Kataoka, K. 2011. Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity. J Control Release 155:296-302.
  • Harada-Shiba, M., Sugisawa, T., Makino, H., Abe, M., Tsushima, M., Yoshimasa, Y., Yamashita, T., Miyamoto, Y., Yamamoto, A., Tomoike, H., et al. 2010. Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia. J Atheroscler Thromb 17:667-674.
  • Kang, J.H., Tachibana, Y., Kamata, W., Mahara, A., Harada-Shiba, M., and Yamaoka, T. 2010. Liver-targeted siRNA delivery by polyethylenimine (PEI)-pullulan carrier. Bioorg Med Chem 18:3946-3950.
  • Harada-Shiba, M., Takamisawa, I., Miyata, K., Ishii, T., Nishiyama, N., Itaka, K., Kangawa, K., Yoshihara, F., Asada, Y., Hatakeyama, K., et al. 2009. Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats. Mol Ther 17:1180-1186.
  • Yamashita, S., Hbujo, H., Arai, H., Harada-Shiba, M., Matsui, S., Fukushima, M., Saito, Y., Kita, T., and Matsuzawa, Y. 2008. Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan. J Atheroscler Thromb 15:292-303.
  • Harada-Shiba, M., Takagi, A., Marutsuka, K., Moriguchi, S., Yagyu, H., Ishibashi, S., Asada, Y., and Yokoyama, S. 2004. Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo. Circ Res 95:945-952.
  • Harada-Shiba, M., Takagi, A., Miyamoto, Y., Tsushima, M., Ikeda, Y., Yokoyama, S., and Yamamoto, A. 2003. Clinical features and genetic analysis of autosomal recessive hypercholesterolemia. J Clin Endocrinol Metab 88:2541-2547.
  • Harada-Shiba, M., Yamauchi, K., Harada, A., Takamisawa, I., Shimokado, K., and Kataoka, K. 2002. Polyion complex micelles as vectors in gene therapy--pharmacokinetics and in vivo gene transfer. Gene Ther 9:407-414.
受賞
第13回湖医会賞受賞
学位 医学博士
所属学会 日本動脈硬化学会、遺伝子・デリバリー研究会、日本アフェレシス学会、日本糖尿病学会、日本循環器学会、日本遺伝子治療学会、日本人工臓器学会、日本生化学会、日本分子生物学会、日本DDS学会、日本薬剤学会、日本内科学会
教育活動 大阪大学招聘教授、大阪大学連携教授、滋賀医科大学医学部非常勤講師、宮崎大学医学部非常勤講師
その他の活動 日本学術会議連携会員、厚生労働省原発性高脂血症に関する調査研究班班員、日本動脈硬化学会学術委員会委員、プルグラム委員会委員、脂質代謝部会委員、Journal of Atherosclerosis and Thrombosis編集委員
日本アフェレシス学会理事
研究者情報

J-GLOBAL: http://jglobal.jst.go.jp/public/20090422/200901069729452309
NII研究者リゾルバー: http://rns.nii.ac.jp/nr/1000070271575

リンク

最終更新日 2015年04月01日

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