国立循環器病研究センター研究所

  • 文字サイズ変更
  • 小
  • 中
  • 大

サイトマップENGLISH

  • 研究所について
  • プロジェクト研究
  • 組織・各部の紹介
  • 産学連携

組織・各部の紹介　循環動態制御部

神谷　厚範

氏名 神谷　厚範 NoPhoto
よみ かみや　あつのり
所属・職務 循環動態制御部研究員
内線番号 2427
FAX番号 06‐6835‐5403
Eメール kamiya@ri.ncvc.go.jp
専門 医学生理学に制御工学を融合した新領域
  • 自律神経系と循環系のシステム生理学、システム生体医工学
  • 生体を閉ループ制御するインテリジェント自動医療
  • 光自律神経科学（光観察と光操作）

生理学に制御工学を導入した医工融合によって、生体をシステム同定・予測するシステム生理学研究、さらに生体を閉ループ制御（＝治療）するインテリジェント自動医療の開発研究が専門です。 自律神経系は、生体情報に応じて全身臓器を個別に調節して適切に連関させ、生体恒常性（循環・呼吸・代謝・体温調節等）を維持する一方、その神経異常は循環器疾患・生活習慣病・ストレス関連疾患などの多様な難治性疾患と深く関わっています。そこで脳・自律神経系の生理的機能や仕組みを解明すると共に、病態においては、脳自律神経回路に先端工学的に介入して、治療に合理的なように神経機能を操作したり再建再構築し、疾患の克服に繋げるような未来医療を創るのが目標です。この手段として、最近では、自律神経系の細胞動態を生きた個体内で光観察する研究や光操作する研究も進めています。
主要論文・著書 2012年1月19日更新
  • 欧文原著　総数８２編　（主著２２編、共著６０編）
  • その他欧文論文（pubmed掲載のproceeding等）　２９編
欧文原著論文
  1. Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M. Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulating baroreflex control. Circ J. 2011 Dec 22;76(1):152-9.
  2. Kawada T, Shimizu S, Li M, Kamiya A, Uemura K, Sata Y, Yamamoto H, Sugimachi M. Contrasting effects of moderate vagal stimulation on heart rate and carotid sinus baroreflex-mediated sympathetic arterial pressure regulation in rats. Life Sci. 2011 Sep 26;89(13-14):498-503.
  3. Shimizu S, Une D, Shishido T, Kamiya A, Kawada T, Sano S, Sugimachi M. Norwood procedure with non-valved right ventricle to pulmonary artery shunt improves ventricular energetics despite the presence of diastolic regurgitation: a theoretical analysis. J Physiol Sci. 2011 Nov;61(6):457-65.
  4. Miyamoto T, Inagaki M, Takaki H, Kawada T, Shishido T, Kamiya A, Sugimachi M. Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes. Eur J Appl Physiol. 2011 (in press)
  5. Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M. Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits. Auton Neurosci. 2011 Jul 5;162(1-2):60-5.
  6. Kamiya A, Kawada T, Shimizu S, Sugimachi M. Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc: predictability analysis. J Physiol 2011 Apr 1;589(Pt 7):1769-90.
  7. Mizuno M, Kawada T, Kamiya A, Miyamoto T, Shimizu S, Shishido T, Smith SA, Sugimachi M. Exercise training augments the dynamic heart rate response to vagal but not sympathetic stimulation in rats. Am J Physiol Regul Integr Comp Physiol. 2011 (in press)
  8. Yamamoto H, Kawada T, Kamiya A, Miyazaki S, Sugimachi M. Involvement of the mechanoreceptors in the sensory mechanisms of manual and electrical acupuncture. Auton Neurosci. 2011 Feb 24;160(1-2):27-31. Epub 2010 Dec 16. PMID: 21167796
  9. Kawada T, Shimizu S, Kamiya A, Sata Y,Uemura K, Sugimachi M. Dynamic characteristics of baroreflex neural and peripheral arcs are preserved in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R155-65. Epub 2010 Nov 3. PMID: 21048073
  10. Une D, Shimizu S, Kamiya A, Kawada T, Shishido T, Sugimachi M. Both skeletonized and pedicled internal thoracic arteries supply adequate graft flow after coronary artery bypass grafting even during intense sympathoexcitation. J Physiol Sci. 2010 Nov;60(6):407-13. Epub 2010 Sep 14. PMID: 20839081
  11. Mizuno M, Kawada T, Kamiya A, Miyamoto T, Shimizu S, Shishido T, Smith SA, Sugimachi M. Dynamic characteristics of heart rate control by the autonomic nervous system in rats. Exp Physiol. 2010 Sep;95(9):919-25. Epub 2010 May 28. PMID: 20511330
  12. Kawada T, Li M, Kamiya A, Shimizu S, Uemura K, Yamamoto H, Sugimachi M. Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction. J Physiol Sci. 2010 Jul;60(4):283-98. PMID: 20514557
  13. Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Sata Y, Shirai M, Sugimachi M. Large conductance Ca2+-activated K+ channels inhibit vagal acetylcholine release at the rabbit sinoatrial node. Auton Neurosci. 2010;156(1-2):149-51.
  14. Kamiya A, Kawada T, Mizuno M, Shimizu S, Sugimachi M. Parallel resetting of arterial baroreflex control of renal and cardiac sympathetic nerve activities during upright tilt in rabbits. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1966-75. PMID: 20348221
  15. Shimizu S, Shishido T, Une D, Kamiya A, Kawada T,Sano S, Sugimachi M. Right Ventricular Stiffness Constant as a Predictor of Postoperative Hemodynamics in Patients with Hypoplastic Right Ventricle: A Theoretical Analysis. J Physiol Sci. 2010 May;60(3): 205-12. PMID: 20131025
  16. Shimizu S, Akiyama T, Kawada T, Shishido T, Mizuno M, Kamiya A, Yamazaki T, Sano S, Sugimachi M. In vivo direct monitoring of interstitial norepinephrine levels at the sinoatrial node. Auton Neurosci. 2010 Jan 15;152(1-2):115-8. Epub 2009 Sep 19. PMID: 19767249
  17. Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Li M, Shirai M, Sugimachi M. Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: a possible trigger for ischemic preconditioning. Life Sci 2009 Oct; 85(15-16): 597-601. PMID: 19733187
  18. Kawada T, Kamiya A, Li M, Shimizu S, Uemura K, Yamamoto H, Sugimachi M. High levels of circulating angiotensin II shift the open-loop baroreflex control of splanchnic sympathetic nerve activity, heart rate and arterial pressure in anesthetized rats. J Physiol Sci. 2009 Nov;59(6):447-55. Epub 2009 Aug 18.PMID: 19688237
  19. Kamiya A, Kawada T, Shimizu S, Iwase S, Sugimachi M, Tadaaki Mano T. Slow head-up tilt causes lower activation of muscle sympathetic nerve activity: loading speed-dependence of orthostatic sympathetic activation in humans. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1): H53-8. PMID: 19448145
  20. Kawada T, Mizuno M, Shimizu S, Uemura K, Kamiya A, Sugimachi M. Angiotensin II disproportionally attenuates dynamic vagal and sympathetic heart rate controls. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1666-74. PMID: 19252092
  21. Shimizu S, Akiyama T, Kawada T, Shishido T, Yamazaki T, Kamiya A, Mizuno M, Sano S, Sugimachi M. In vivo direct monitoring of vagal acetylcholine release to the sinoatrial node. Auton Neurosci: 2009 Mar 9, 148: 44 49. PMID: 19278905
  22. Kawada T, Shimuzu S, Yamamoto H, Shishido T, Kamiya A, Miyamoto T, Sunagawa K, Sugimachi M. Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control. Circ J. 2009 May;73(5):851-9. PMID: 19293530
  23. Yamamoto H, Kawada T, Kamiya A, Kita T, Sugimachi M. Electroacupuncture changes the relationship between cardiac and renal sympathetic nerve activities in anesthetized cats. Auton Neurosci. 2008 Dec 15;144(1-2):43-9. PMID: 18990613
  24. Mizuno M, Kamiya A, Kawada T, Miyamoto T, Shimizu S, Shishido T, Sugimachi M. Accentuated antagonism in vagal heart rate control mediated through muscarinic potassium channels. J Physiol Sci. 2008 Dec;58(6):381-8. PMID: 18842163
  25. Miyamoto T, Kawada T, Yanagiya Y, Akiyama T, Kamiya A, Mizuno M, Takaki H, Sunagawa K, Sugimachi M. Contrasting effects of intrinsic operation and extrinsic activation of presynaptic {alpha}2-adrenergic inhibition on sympathetic heart rate control. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1855-66. PMID: 18757478
  26. Yamamoto K, Kawada T, Kamiya A, Takaki H, Shishido T, Sunagawa K, Sugimachi M. Muscle mechanoreflex augments arterial baroreflex-mediated dynamic sympathetic response to carotid sinus pressure. Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1081-H1089. PMID: 18586892
  27. Kamiya A, Michikami D, Iwase S, Mano T. Decoding rule from vasoconstrictor skin sympathetic nerve activity to nonglabrous skin blood flow in humans at normothermic rest. Neurosci Lett. 2008 Jul 4;439(1):13-7. Epub 2008 Apr 10.PMID: 18502048
  28. Kamiya A, Kawada T, Yamamoto K, Mizuno M, Shimizu S, Sugimachi M. Upright tilt resets dynamic transfer function of baroreflex neural arc to minify the pressure disturbance in total baroreflex control. J Physiol Sci. 2008 Jun;58(3):189-98. Epub 2008 May 13.PMID: 18471343
  29. Uemura K, Li M, Tsutsumi T, Yamazaki T, Kawada T, Kamiya A, Inagaki M, Sunagawa K, Sugimachi M. Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2254-61. PMID: 17693545
  30. Kawada T, Kitagawa H, Yamazaki T, Akiyama T, Kamiya A, Uemura K, Mori H, Sugimachi M. Hypothermia reduces ischemia- and stimulation-induced myocardial interstitial norepinephrine and acetylcholine releases. J Appl Physiol. 2007 Feb;102(2):622-7. PMID: 17082372
  31. Nakaoka Y, Nishida K, Narimatsu M, Kamiya A, Minami T, Sawa H, Okawa K, Fujio Y, Koyama T, Maeda M, Sone M, Yamasaki S, Arai Y, Koh GY, Kodama T, Hirota H, Otsu K, Hirano T, Mochizuki N. Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. J Clin Invest 2007 Jul;117(7):1771-81. PMID: 17571162
  32. Mizuno M, Kamiya A, Kawada T, Miyamoto T, Shimizu S, Sugimachi M. Muscarinic potassium channels augment dynamic and static heart rate Responses to vagal stimulation. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1564-70. PMID: 17526651
  33. Kawada T, Yamazaki T, Akiyama T, Uemura K, Kamiya A, Shishido T, Mori H, Sugimachi M. Effects of Ca2+ channel antagonists on nerve stimulation-induced and ischemia-induced myocardial interstitial acetylcholine release in cats. Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2187-91. PMID: 16766645
  34. Kawada T, Miyamoto T, Miyoshi Y, Yamaguchi S, Tanabe Y, Kamiya A, Shishido T, Sugimachi M. Sympathetic neural regulation of heart rate is robust against high plasma catecholamines. J Physiol Sci. 2006 Jun;56(3):235-45. PMID: 16839462
  35. Kamiya A, Kawada T, Mizuno M, Miyamoto T, Uemura K, Seki K, Shimizu S, Sugimachi M. Baroreflex increases correlation and coherence of muscle sympathetic nerve activity (SNA) with renal and cardiac SNAs. J Physiol Sci. 2006 Oct;56(5):325-33. PMID: 16956421
  36. Uemura K, Kamiya A, Hidaka I, Kawada T, Shimizu S, Shishido T, Yoshizawa M, Sugimachi M, Sunagawa K. Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure. J Appl Physiol. 2006 Apr;100(4):1278-86. PMID: 16373447
  37. Michikami D, Kamiya A, Kawada T, Inagaki M, Shishido T, Yamamoto K, Ariumi H, Iwase S, Sugenoya J, Sunagawa K, Sugimachi M. Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H318-26. PMID: 16501021
  38. Aiba T, Shimizu W, Hidaka I, Uemura K, Noda T, Zheng C, Kamiya A, Inagaki M, Sugimachi M, Sunagawa K. Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study. J Am Coll Cardiol. 2006 May 16;47(10):2074-85. PMID: 16697328
  39. Hirayanagi K, Iwase S, Kamiya A, Watanabe Y, Shiozawa T, Yamaguchi N, Yajima K, Mano T.Alternations of static cerebral and systemic circulation in normal humans during 14-day head-down bed rest. Med Sci Monit. 2005 Dec;11(12):CR570-5. PMID: 16319787
  40. Hayano J, Barros AK, Kamiya A, Ohte N, Yasuma F. Assessment of pulse rate variability by the method of pulse frequency demodulation. Biomed Eng Online. 2005 Nov 1;4:62. PMID: 16259639
  41. Kamiya A, Kawada T, Yamamoto K, Michikami D, Ariumi H, Uemura K, Zheng C, Shimizu S, Aiba T, Miyamoto T, Sugimachi M, Sunagawa K. Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits. J Physiol. 2005 Jul 1;566(Pt 1):237-46. PMID: 15878944
  42. Kamiya A, Hayano J, Kawada T, Michikami D, Yamamoto K, Ariumi H, Shimizu S, Uemura K, Miyamoto T, Aiba T, Sunagawa K, Sugimachi M. Low frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia. Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1758-69. PMID: 15937091
  43. Kawada T, Yamamoto K, Kamiya A, Ariumi H, Michikami D, Shishido T, Sunagawa K, Sugimachi M. Dynamic Characteristics of Carotid Sinus Pressure-Nerve Activity Transduction in Rabbits. Jpn J Physiol. 2005 Jun;55(3):157-63. PMID: 16079025
  44. Kamiya A, Kawada T, Yamamoto K, Michikami D, Ariumi H, Miyamoto T, Shimizu S, Uemura K, Aiba T, Sunagawa K, Sugimachi M. Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2641-8. PMID: 16055514
  45. Iwasaki KI, Shiozawa T, Kamiya A, Michikami D, Hirayanagi K, Yajima K, Iwase S, Mano T. Hypergravity exercise against bed rest induced changes in cardiac autonomic control. Eur J Appl Physiol. 2005 Jun;94(3):285-91. PMID: 15765240
  46. Uemura K, Kawada T, Kamiya A, Aiba T, Hidaka I, Sunagawa K, Sugimachi M. Prediction of circulatory equilibrium in response to changes in stressed blood volume. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H301-7. PMID: 15708956
  47. Kamiya A, Kawada T, Yamamoto K, Michikami D, Ariumi H, Miyamoto T, Uemura K, Sugimachi M, and Sunagawa K. Muscle sympathetic nerve activity averaged over 1 minute parallels renal and cardiac sympathetic nerve activity in response to a forced baroreceptor pressure change. Circulation. 2005 Jul 19;112(3):384-6. PMID: 15998668
  48. Yamamoto K, Kawada T, Kamiya A, Takaki H, Sugimachi M, Sunagawa K. Static interaction between muscle mechanoreflex and arterial baroreflex in determining efferent sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1604-9. PMID: 15908461
  49. Kamiya A, Michikami D, Shiozawa T, Iwase S, Hayano J, Kawada T, Sunagawa K, Mano T. Bed rest attenuates sympathetic and pressor responses to isometric exercise in antigravity leg muscles in humans. Am J Physiol Regul Integr Comp Physiol. 2004 May;286(5):R844-50. PMID: 14701716
  50. Hirayanagi K, Iwase S, Kamiya A, Sasaki T, Mano T, Yajima K. Functional changes in autonomic nervous system and baroreceptor reflex induced by 14 days of 6 degrees head-down bed rest. Eur J Appl Physiol. 2004 Jun;92(1-2):160-7. PMID: 15042373
  51. Hirayanagi K, Kamiya A, Iwase S, Mano T, Sasaki T, Oinuma M, Yajima K. Autonomic cardiovascular changes during and after 14 days of head-down bed rest. Auton Neurosci. 2004 Feb 27;110(2):121-8. PMID: 15046736
  52. Yanagiya Y, Sato T, Kawada T, Inagaki M, Tatewaki T, Zheng C, Kamiya A, Takaki H, Sugimachi M, Sunagawa K. Bionic epidural stimulation restores arterial pressure regulation during orthostasis. J Appl Physiol. 2004 Sep;97(3):984-90. PMID: 15133002
  53. Uemura K, Sugimachi M, Kawada T, Kamiya A, Jin Y, Kashihara K, Sunagawa K. A Novel Framework of Circulatory Equilibrium. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2376-85. PMID: 14764438
  54. Kawada T, Miyamoto T, Uemura K, Kashihara K, Kamiya A, Sugimachi M, Sunagawa K. Effects of neuronal norepinephrine uptake blockade on baroreflex neural and peripheral arc transfer characteristics. Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1110-20. PMID: 14962824
  55. Kawada T, Uemura K, Kashihara K, Kamiya A, Sugimachi M, Sunagawa K. A derivative-sigmoidal model reproduces operating-point dependent baroreflex neural arc transfer characteristics. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2272-9. PMID: 14962840
  56. Yamamoto K, Kawada T, Kamiya A, Takaki H, Miyamoto T, Sugimachi M, Sunagawa K. Muscle mechanoreflex induces the pressor response by resetting the arterial baroreflex neural arc. Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1382-8. PMID: 14630630
  57. Michikami D, Kamiya A, Fu Q, Iwase S, Mano T, Sunagawa K. Attenuated thermoregulatory sweating and cutaneous vasodilation after 14-day bed rest in humans. J Appl Physiol. 2004 Jan;96(1):107-14. PMID: 12949026
  58. Kamiya A, Michikami D, Iwase S, Hayano J, Kawada T, Sugimachi M, Sunagawa K. Alpha-adrenergic vascular responsiveness to sympathetic nerve activity is intact after head-down bed rest in humans. Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R151-7. PMID: 12958062
  59. Kamiya A, Michikami D, Hayano J, Sunagawa K. Heat stress modifies human baroreflex function independently of heat-induced hypovolemia. Jpn J Physiol. 2003 Jun;53(3):215-22. PMID: 14529582
  60. Kamiya A, Michikami D, Fu Q, Iwase S, Hayano J, Kawada T, Mano T, Sunagawa K. Pathophysiology of orthostatic hypotension after bed rest: paradoxical sympathetic withdrawal. Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1158-67. PMID: 12714328
  61. Fu Q, Iwase S, Niimi Y, Kamiya A, Michikami D, Mano T, Suzumura A. Age-related changes in vasomotor reflex control of calf venous capacitance response to lower body negative pressure in humans. Jpn J Physiol. 2002 Feb;52(1):69-76. PMID: 12047804
  62. Fu Q, Iwase S, Niimi Y, Kamiya A, Michikami D, Mano T, Suzumura A. Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans. Jpn J Physiol. 2002 Feb;52(1):77-84. PMID: 12047805
  63. Iwase S, Cui J, Wallin BG, Kamiya A, Mano T. Effects of increased ambient temperature on skin sympathetic nerve activity and core temperature in humans. Neurosci Lett. 2002 Jul 12;327(1):37-40. PMID: 12098495
  64. Michikami D, Kamiya A, Fu Q, Niimi Y, Iwase S, Mano T, Suzumura A. Forearm elevation augments sympathetic activation during handgrip exercise in humans. Clin Sci (Lond). 2002 Sep;103(3):295-301. PMID: 12193155
  65. Iwase S, Mano T, Kamiya A, Niimi Y, Fu Q, Suzumura A. Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans. Auton Neurosci. 2002 Jan 10;95(1-2):141-5. PMID: 11871780
  66. Fu Q, Vinogradova OL, Kamiya A, Michikami D, Cui J, Niimi Y, Iwase S, Mano T. Effects of simulated microgravity on leg venous compliance in orthostatic intolerance. Aviakosm Ekolog Med. 2002;36(3):46-50. PMID: 12222071
  67. Michikami D, Iwase S, Kamiya A, Qi F, Mano T, Suzumura A. Interrelations of vasoconstrictor sympathetic outflow to skin core temperature during unilateral sole heating in humans. Auton Neurosci. 2001 Aug 13;91(1-2):55-61. PMID: 11515802
  68. Fu Q, Iwase S, Niimi Y, Kamiya A, Kawanokuchi J, Cui J, Mano T, Suzumura A. Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt. Am J Physiol Regul Integr Comp Physiol. 2001 Sep;281(3):R778-85. PMID: 11506992
  69. Iwase S, Okamoto T, Mano T, Kamiya A, Niimi Y, Qi F, Nishikimi N, Sakurai T, Nimura Y. Skin sympathetic outflow in Buerger's disease. Auton Neurosci. 2001 Mar 23;87(2-3):286-92. PMID: 11476291
  70. Nomura T, Kawano F, Ishihara A, Sato Y, Mitarai G, Iwase S, Kamiya A, Mano T, Ohira Y. Enhanced Hoffman-reflex in human soleus muscle during exposure to microgravity environment. Neurosci Lett. 2001 Dec 4;316(1):55-7. PMID: 11720777
  71. Kamiya A, Michikami D, Fu Q, Niimi Y, Iwase S, Mano T, Suzumura A. Static handgrip exercise modifies arterial baroreflex control of vascular sympathetic outflow in humans. Am J Physiol Regul Integr Comp Physiol. 2001 Oct;281(4):R1134-9. PMID: 11557620
  72. Iwase S, Yamamoto K, Miwa C, Kamiya A, Niimi Y, Fu Q, Mano T. Skin sympathetic neuroeffector response is attenuated dose-dependently by systemic prostaglandin E1 injection in humans. Neurosci Lett. 2000 Oct 13;292(3):191-4. PMID: 11018309
  73. Kamiya A, Iwase S, Michikami D, Fu Q, Mano T. Head-down bed rest alters sympathetic and cardiovascular responses to mental stress. Am J Physiol Regul Integr Comp Physiol. 2000 Aug;279(2):R440-7. PMID: 10938230
  74. Fu Q, Sugiyama Y, Kamiya A, Mano T. A comparison of autonomic responses in humans induced by two simulation models of weightlessness: lower body positive pressure and 6 degrees head-down tilt. J Auton Nerv Syst. 2000 Apr 12;80(1-2):101-7. PMID: 10742547
  75. Iwase S, Sugiyama Y, Miwa C, Kamiya A, Mano T, Ohira Y, Shenkman B, Egorov AI, Kozlovskaya IB. Effects of three days of dry immersion on muscle sympathetic nerve activity and arterial blood pressure in humans. J Auton Nerv Syst. 2000 Mar 15;79(2-3):156-64. PMID: 10699647
  76. Kamiya A, Iwase S, Michikamia D, Fu Q, Mano T. Muscle sympathetic nerve activity during handgrip and post-handgrip muscle ischemia after exposure to simulated microgravity in humans. Neurosci Lett. 2000 Feb 11;280(1):49-52. PMID: 10696809
  77. Kamiya A, Iwase S, Michikami D, Fu Q, Mano T, Kitaichi K, Takagi K. Increased vasomotor sympathetic nerve activity and decreased plasma nitric oxide release after head-down bed rest in humans: disappearance of correlation between vasoconstrictor and vasodilator. Neurosci Lett. 2000 Mar 3;281(1):21-4. PMID: 10686406
  78. Kamiya A, Iwase S, Sugiyama Y, Mano T, Sudoh M. Vasomotor sympathetic nerve activity in men during bed rest and on orthostasis after bed rest. Aviat Space Environ Med. 2000 71(2):142-9.
  79. Kamiya A, Iwase S, Kitazawa H, Mano T, Vinogradova OL, Kharchenko IB. Baroreflex control of muscle sympathetic nerve activity after 120 days of 6 degrees head-down bed rest. Baroreflex control of muscle sympathetic nerve activity after 120 days of 6 degrees head-down bed rest. Am J Physiol Regul Integr Comp Physiol. 2000 Feb;278(2):R445-52. PMID: 10666146
  80. Iwase S, Mano T, Cui J, Kitazawa H, Kamiya A, Miyazaki S, Sugiyama Y, Mukai C, Nagaoka S. Sympathetic outflow to muscle in humans during short periods of microgravity produced by parabolic flight. Am J Physiol. 1999 Aug;277(2 Pt 2):R419-26. PMID: 10444548
  81. Fu Q, Sugiyama Y, Kamiya A, Shamsuzzaman AS, Mano T. Responses of muscle sympathetic nerve activity to lower body positive pressure. Am J Physiol. 1998 Oct;275(4 Pt 2):H1254-9. PMID: 9746473
  82. Shamsuzzaman AS, Sugiyama Y, Kamiya A, Fu Q, Mano T. Head-up suspension in humans: effects on sympathetic vasomotor activity and cardiovascular responses. J Appl Physiol. 1998 May;84(5):1513-9. PMID: 9572793

その他の欧文論文（pubmed掲載の年報やproceeding等）
  1. Sugimachi M, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T. Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs. Conf Proc IEEE Eng Med Biol Soc. 1:2030-2, 2009. PMID: 19964770
  2. Sugimachi M, Kawada T, Yamamoto H, Kamiya A, Miyamoto T, Sunagawa K. Modification of autonomic balance by electrical acupuncture does not affect baroreflex dynamic characteristics. Conf Proc IEEE Eng Med Biol Soc. 1981-4, 2008. PMID: 19163080
  3. Sugimachi M, Kawada T, Kamiya A, Li M, Zheng C, Sunagawa K. Electrical acupuncture modifies autonomic balance by resetting the neural arc of arterial baroreflex system. Conf Proc IEEE Eng Med Biol Soc. 5334-7, 2007. PMID: 18003212
  4. Uemura K, Kamiya A, Shimizu S, Shishido T, Sugimachi M, Sunagawa K. Comprehensive physiological cardiovascular model enables automatic correction of hemodynamics in patients with acute life-threatening heart failure. Conf Proc IEEE Eng Med Biol Soc. 1:198-201, 2006. PMID: 17945972
  5. Miyamoto T, Inagaki M, Takaki H, Kamiya A, Kawada T, Shishido T, Sugimachi M, Sunagawa K. Sensitized central controller of ventilation in rats with chronic heart failure contributes to hyperpnea little at rest but more during exercise. Conf Proc IEEE Eng Med Biol Soc. 1:4627-30, 2006. PMID: 17946641
  6. Kawanokuchi J, Fu Q, Cui J, Niimi Y, Kamiya A, Michikami D, Iwase S, Mano T, Suzumura A. Influence of vestibulo-sympathetic reflex on muscle sympathetic outflow during head-down tilt. Environ Med. 45(2):66-8, 2001. PMID: 12353535
  7. Michikami D, Kamiya A, Fu Q, Niimi Y, Iwase S, Mano T, Suzumura A. Effect of simulated microgravity exposure on thermoregulatory control of sweating. Environ Med. 45(2):58-61, 2001. PMID: 12353534
  8. Fu Q, Iwase S, Niimi Y, Kamiya A, Kawanokuchi J, Cui J, Mano T. Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt. J Gravit Physiol. 8(1):P83-4, 2001. PMID: 12650184
  9. Kamiya A, Michikami D, Fu Q, Niimi Y, Iwase S. Muscle sympathetic nerve activity (MSNA) during high-intensity, isometric leg exercise in humans. Environ Med. 44(1):49-52, 2000. PMID: 12296370
  10. Michikami D, Kamiya A, Qi F, Niimi Y, Iwase S, Mano T. Arm elevation enhances muscle sympathetic nerve activity during static exercise. Environ Med. 44(1):46-8, 2000. PMID: 12296369
  11. Niimi Y, Iwase S, Fu Q, Kamiya A, Mano T. Effect of aging on muscle sympathetic nerve activity and peripheral venous pressure in humans. Environ Med. 44(1):56-9, 2000. PMID: 12296371
  12. Fu Q, Iwase S, Kamiya A, Michikami D, Niimi Y, Mano T. Leg venous compliance in orthostatic intolerance before and after 14-day head-down bed rest. Environ Med. 44(1):53-5, 2000. PMID: 11758569
  13. Fu Q, Iwase S, Niimi Y, Kamiya A, Michikami D, Mano T. Effects of leg venous hemodynamics on cardiovascular responses to lower body negative pressure and aging. J Gravit Physiol. 7(2):P161-2, 2000. PMID: 12697523
  14. Fu Q, Iwase S, Kamiya A, Michikami D, Niimi Y, Mano T. Regulation of the venous capacitance during microgravity. J Gravit Physiol. 7(2):P19-22, 2000. PMID: 12697543
  15. Cui J, Iwase S, Mano T, Niimi Y, Fu Q, Michikami D, Atsuta S, Kamiya A, Ushui H. Body temperature and skin blood flow during a 14-day bed-rest in a head-down tilt position in humans. J Gravit Physiol. 7(2):P133-4, 2000. PMID: 12697497
  16. Michikami D, Kamiya A, Fu Q, Cui J, Usui H, Atsuta S, Niimi Y, Iwase S, Mano T. Responses of muscle sympathetic nerve activity to static handgrip exercise after 14 days of exposure to simulated microgravity. J Gravit Physiol. 7(2):P175-6, 2000. PMID: 12697516
  17. Kamiya A, Michikami D, Fu Q, Niimi Y, Iwase S, Mano T. Arterial baroreflex control of sympathetic vasoconstrictor traffic and orthostatic intolerance after head-down bed rest. J Gravit Physiol. 7(2):P177-8, 2000. PMID: 12697515
  18. Fu Q, Iwase S, Niimi Y, Kamiya A, Michikami D, Mano T. Effects of aging on leg vein filling and venous compliance during low levels of lower body negative pressure in humans. Environ Med. 43(2):142-5, 1999. PMID: 12296367
  19. Kamiya A, Iwase S, Kitazawa H, Mano T. Muscle sympathetic nerve activity (MSNA) after 120 days of 6 degrees head-down bed rest (HDBR). Environ Med. 43(2):150-2, 1999. PMID: 11762388
  20. Kamiya A, Michikami D, Fu Q, Iwase S, Mano T. Sympathetic vasoconstriction and orthostatic intolerance after simulated microgravity. J Gravit Physiol. 6(1):P101-2, 1999. PMID: 11542976
  21. Fu Q, Sugiyama Y, Kamiya A, Iwase S, Mano T. A comparison of the effects of lower body positive pressure and head-down tilt on cardiovascular responses in humans. J Gravit Physiol. 6(1):P111-2, 1999. PMID: 11542981
  22. Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T. Macroscopic two-pump two-vasculature cardiovascular model to support treatment of acute heart failure. Conf Proc IEEE Eng Med Biol Soc. 1:2365-8, 2009. PMID: 19965188
  23. Sugimachi M, Sunagawa K, Uemura K, Kamiya A, Shimizu S, Inagaki M, Shishido T. Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change. Conf Proc IEEE Eng Med Biol Soc. 1:5205-8, 2010. PMID: 21096038
  24. Kamiya A, Michikami D, Fu Q, Iwase S, Mano T. Vasomotor sympathetic nerve responses to static handgrip after simulated microgravity. J Gravit Physiol. 6(1):P153-4, 1999. PMID: 11543001
  25. Iwase S, Jian C, Kitazawa H, Kamiya A, Miyazaki S, Sugiyama Y, Mukai C, Kohno M, Mano T, Nagaoka S. Changes in muscle sympathetic nerve activity and effects of breathing maneuvers in humans during microgravity induced by parabolic flight. J Gravit Physiol. 6(1):P71-2, 1999. PMID: 11543033
  26. Iwase S, Mano T, Cui J, Kitazawa H, Kamiya A, Miyazaki S, Sugiyama Y, Mukai C, Kohno M, Nagaoka S. Changes in muscle sympathetic nerve activity and effect of breathing maneuvers during microgravity induced by parabolic flight in humans. Environ Med. 42(2):152-5, 1998. PMID: 11542691
  27. Fu Q, Sugiyama Y, Kamiya A, Shamsuzzaman AS, Mano T. Effects of lower body positive pressure on muscle sympathetic nerve activity. Environ Med. 42(1):76-8, 1998. PMID: 12212620
  28. Kamiya A, Sugiyama Y, Iwase S, Mano T. Muscle sympathetic nerve activity and plasma norepinephrine during 6 degrees head-down bed rest. Environ Med. 42(2):159-62, 1998. PMID: 11542692
  29. Mano T, Iwase S, Kamiya A. Sympathetic nerve responses in humans to short and long term simulation of microgravity. J Gravit Physiol. 5(1):P93-6, 1998. PMID: 11542379
受賞
  • 平成12年　第１回 Neurocardiology Workshop奨励賞
  • 平成18年　第4回 交感神経とアンギオテンシン研究会優秀賞
  • 平成19年　第1回 日本生理学会循環生理学優秀論文賞　など
学位 医学博士（名古屋大学医学部大学院）
所属学会 日本生理学会（評議員）、日本自律神経学会（評議員）、日本宇宙航空環境医学会（評議員）、日本循環制御医学会（評議員）、日本循環器学会、日本生体医工学会など
教育活動
  • 名古屋大学医学部（講義・実習）
  • 名古屋大学医学部大学院（講義・実習）
  • 岐阜大学医学部非常勤講師（生理学）
  • 大阪大学学位審査
  • 九州大学学位審査　など
その他の活動 2011年4月5日更新
研究費受入実績（2002-2011年度の10年間）
  • 研究費総額　４９９,４６５,０００円
  • 研究代表分　４８４,０２８,０００円
  • 2001-2002
    科学研究費補助金奨励研究A
    長期臥床による筋萎縮と、運動時の心循環・体温調節系応答の変化
    代表 1,800（千円）
  • 2003-2005
    (独)新エネルギー・産業技術総合開発機構産業技術研究助成事業
    自律神経制御による心筋梗塞の画期的治療法の開発：非侵襲的頚部吸引装置の開発
    代表 49,920（千円）
  • 2004
    (財)循環器病研究振興財団公募研究助成
    交感神経を抑制し、迷走神経を刺激して心不全を治療する電気鍼システムの開発
    代表 1,000（千円）
  • 2004-2006
    (財)日本宇宙フォーラム宇宙環境利用に関する公募地上研究
    宇宙環境における遠隔自動治療システムの基盤技術の開発
    代表 34,650（千円）
  • 2006-2007
    科学研究費補助金基盤研究C
    心拍出量を増加させる閉ループ心周期人工呼吸の開発
    代表 3,890（千円）
  • 2006-2008
    厚生労働科学研究費補助金医療機器開発推進研究事業（ナノメディシン研究）
    難治性循環器疾患を克服する超小型ナノ神経センサー兼刺激治療装置の開発
    代表 139,728（千円）
  • 2006-2010
    (独)新エネルギー・産業技術総合開発機構産業技術研究助成事業
    患者に合わせて鍼刺激を自動調節し、ヒト自律神経を確実に治療する、サーボ電気鍼臨床実用装置の開発
    代表 63,700（千円）
  • 2008-2010
    科学研究費補助金基盤研究B
    循環管理を支援する自動治療システムを臨床実用化するための研究
    代表 19,240（千円）
  • 2009-2011
    厚生労働科学研究費補助金医療機器開発推進研究事業
    頚動脈洞神経マイクロマシンによって圧反射性に自律神経を自動制御し、心不全を抑制する医療の開発
    代表 161,380（千円）
  • 2009
    厚生労働科学研究費補助金難治性疾患克服研究事業
    わが国初の周産期心筋症の全国後方視的・前方視的症例調査に関する研究
    分担 0（千円）
  • 2010-2011
    厚生労働科学研究費補助金難治性疾患克服研究事業
    わが国初の周産期心筋症の診断治療指針を作成するための臨床研究
    分担 0（千円）
  • 2011-2013
    科学研究費補助金基盤研究B
    循環管理を支援する自動薬物医療システムを臨床実用化し、自律神経医療と統合する研究
    代表 18,850（千円）

特許
6件
研究者情報
リンク
 

最終更新日 2012年01月19日

PAGETOP

国立循環器病研究センター研究所：〒565-8565 大阪府吹田市藤白台5丁目7番1号　電話：06-6833-5012（代）
Copyright © 2011 National Cerebral and Cardiovascular Center All rights reserved.