ホーム > 各部のご紹介 > 心臓生理機能部 > 戦 冬雲

心臓生理機能部

スタッフ紹介 [戦 冬雲]

氏名 戦 冬雲 (Zhan Dong-Yun)
NoPhoto
よみ せん とううん
所属・職務 心臓生理機能部 派遣研究員
内線番号 2381
FAX番号 06-6835-5416
Eメール dyzhan@ncvc.go.jp
棟/部屋番号 研究所本館 6階
専門 生理学、薬理学、循環器内科学、分子生物学
主要論文・著書 論文
  • Du CK, Zhan DY, Akiyama T, Sonobe T, Inagaki T, Shirai M. Myocardial interstitial serotonin and its major metabolite, 5-hydroxyindole acetic acid levels determined by microdialysis technique in rat heart. Life Sci. 117: 33-39 (2014)
  • Du CK, Zhan DY, Morimoto S, Akiyama T, Schwenke DO, Hosoda H, Kangawa K, Shirai M. Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy. Pharmacol Res Perspect. 2: e00064 (2014)
  • Du CK, Zhan DY, Morimoto S. In vivo effects of propyl gallate, a novel Ca2+ sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation. Life Sci. 109: 15-19 (2014)
  • Sonobe T, Akiyama T, Du CK, Zhan DY, Shirai M. Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats. Acta Physiol. 210: 823-831 (2014)
  • Zhan DY, Du CK, Akiyama T, Sonobe T, Tsuchimochi H, Shimizu S, Kawada T, Shirai M. In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anesthetized mice. Auton Neurosci. 76: 91-94 (2013)
  • Sonobe T, Akiyama T, Du CK, Zhan DY, Shirai M. Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischaemia-reperfusion in rabbits. Acta Physiol. 207: 260-268 (2013)
  • Li L, Morimoto S, Take S, Zhan DY, Du CK, Wang YY, Fan XL, Yoshihara T, Takahashi-Yanaga F, Katafuchi T, Sasaguri T. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. J Mol Cell Cardiol. 53: 760-767 (2012)
  • Fan X, Takahashi-Yanaga F, Morimoto S, Zhan DY, Igawa K, Tomooka K, Sasaguri T. Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited dilated cardiomyopathy mouse model. J Pharmacol Exp Ther. 338: 2-11 (2011)
  • Tadano N, Du CK, Yumoto F, Morimoto S, Ohta M, Xie MF, Nagata K, Zhan DY, Lu QW, Miwa Y, Takahashi-Yanaga F, Tanokura M, Ohtsuki I, Sasaguri T. Biological actions of green tea catechins on cardiac troponin C. Br J Pharmacol. 161: 1034-1043 (2010)
  • Toko H, Takahashi H, Kayama Y, Oka T, Minamino T, Okada S, Morimoto S, Zhan DY, Terasaki F, Anderson ME, Inoue M, Yao A, Nagai R, Kitaura Y, Sasaguri T, Komuro I. Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy. Circulation. 122: 891-899 (2010)
  • Wang YY, Morimoto S, Du CK, Lu QW, Zhan DY, Tsutsumi T, Ide T, Miwa Y, Takahashi-Yanaga F, Sasaguri T: Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy. Cardiovasc Res. 87: 636-646 (2010)
  • Sfichi-Duke L, Garcia-Cazarin ML, Sumandea CA, Sievert GA, Balke CW, Zhan DY, Morimoto S, Sumandea MP. Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins. J Mol Cell Cardiol. 48: 934-942 (2010)
  • Arimura T, Sato R, Machida N, Bando H, Zhan DY, Morimoto S, Tanaka R, Yamane Y, Bonne G, Kimura A. Improvement of left ventricular dysfunction and of survival prognosis of dilated cardiomyopathy by administration of calcium sensitizer SCH00013 in a mouse model. J Am Coll Cardiol. 55: 1503-1505 (2010)
  • Zhan DY, Morimoto S, Du CK, Wang YY, Lu QW, Tanaka A, Ide T, Miwa Y, Takahashi-Yanaga F, Sasaguri T. Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation. Cardiovasc Res. 84: 64-71 (2009)
  • Nishii K, Morimoto S, Minakami R, Miyano Y, Hashizume K, Ohta M, Zhan DY, Lu QW, Shibata Y. Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo. Dev Biol. 322: 65-73 (2008)
  • Du CK, Morimoto S, Nishii K, Minakami R, Ohta M, Tadano N, Lu QW, Wang YY, Zhan DY, Mochizuki M, Kita S, Miwa Y, Takahashi-Yanaga F, Iwamoto T, Ohtsuki I, Sasaguri T. Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation. Circ Res. 101: 185-194 (2007)
受賞
第3回日本心臓財団入澤宏・彩記念研究奨励
学位 博士(医学)
所属学会 日本生理学会、日本薬理学会、BIOPHYSICAL SOCIETY 
教育活動
その他の活動
研究者情報
リンク

最終更新日 2015年04月01日

ページ上部へ