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心臓生理機能部

スタッフ紹介 [杜 成坤]

氏名 杜 成坤 (Du Cheng-Kun)
NoPhoto
よみ と せいこん
所属・職務 心臓生理機能部 上級研究員
内線番号 2381
FAX番号 06-6835-5416
Eメール duchk@ncvc.go.jp
棟/部屋番号 研究所本館 6階
専門 生理学、薬理学、循環器内科学
主要論文・著書 論文
  • Du CK, Zhan DY, Akiyama T, Sonobe T, Inagaki T, Shirai M. Myocardial interstitial serotonin and its major metabolite, 5-hydroxyindole acetic acid levels determined by microdialysis technique in rat heart. Life Sci. 117: 33-39 (2014)
  • Du CK, Zhan DY, Morimoto S, Akiyama T, Schwenke DO, Hosoda H, Kangawa K, Shirai M. Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy. Pharmacol Res Perspect. 2: e00064 (2014)
  • Du CK, Zhan DY, Morimoto S. In vivo effects of propyl gallate, a novel Ca2+ sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation. Life Sci. 109: 15-19 (2014)
  • Sonobe T, Akiyama T, Du CK, Zhan DY, Shirai M. Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats. Acta Physiol. 210: 823-831 (2014)
  • Zhan DY, Du CK, Akiyama T, Sonobe T, Tsuchimochi H, Shimizu S, Kawada T, Shirai M. In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anesthetized mice. Auton Neurosci. 76: 91-94 (2013)
  • Sonobe T, Akiyama T, Du CK, Zhan DY, Shirai M. Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischaemia-reperfusion in rabbits. Acta Physiol. 207: 260-268 (2013)
  • Li L, Morimoto S, Take S, Zhan DY, Du CK, Wang YY, Fan XL, Yoshihara T, Takahashi-Yanaga F, Katafuchi T, Sasaguri T. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. J Mol Cell Cardiol. 53: 760-767 (2012)
  • Tadano N, Du CK, Yumoto F, Morimoto S, Ohta M, Xie MF, Nagata K, Zhan DY, Lu QW, Miwa Y, Takahashi-Yanaga F, Tanokura M, Ohtsuki I, Sasaguri T. Biological actions of green tea catechins on cardiac troponin C. Br J Pharmacol. 161: 1034-1043 (2010)
  • Wang YY, Morimoto S, Du CK, Lu QW, Zhan DY, Tsutsumi T, Ide T, Miwa Y, Takahashi-Yanaga F, Sasaguri T. Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy. Cardiovasc Res. 87: 636-646 (2010)
  • Zhan DY, Morimoto S, Du CK, Wang YY, Lu QW, Tanaka A, Ide T, Miwa Y, Takahashi-Yanaga F, Sasaguri T. Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation. Cardiovasc Res. 84: 64-71 (2009)
  • Mizukami Y, Ono K, Du CK, Aki T, Hatano N, Okamoto Y, Ikeda Y, Ito H, Hamano K, Morimoto S. Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion. Cardiovasc Res. 79: 589-599 (2008)
  • Du CK, Morimoto S, Nishii K, Minakami R, Ohta M, Tadano N, Lu QW, Wang YY, Zhan DY, Mochizuki M, Kita S, Miwa Y, Takahashi-Yanaga F, Iwamoto T, Ohtsuki I, Sasaguri T. Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation. Circ Res. 101: 185-194 (2007)
  • Lu QW, Morimoto S, Harada K, Du CK, Takahashi-Yanaga F, Miwa Y, Sasaguri T, Ohtsuki I. Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization. J Mol Cell Cardiol. 35: 1421-1427 (2003)
受賞
学位 博士(医学)
所属学会 日本生理学会、日本薬理学会、日本心血管内分泌代謝学会、
BIOPHYSICAL SOCIETY
教育活動
その他の活動
研究者情報
リンク

最終更新日 2015年04月01日

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