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白井 学

氏名 白井 学 NoPhoto
よみ しらい まなぶ
所属・職務 統合オミックス情報解析室 室長
内線番号
FAX番号
Eメール
棟/部屋番号
専門 心臓発生、エピジェネティクス
主要論文・著書 Google Scholar Citationsに全ての業績を公開

論文
  • Arita Y, Nakaoka Y, Shirai M, Komuro I. et al.(員数26、14番目) Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart. Nat. Commun. 5, 4552 (2014).
  • Ohno, Y., Shirai, M., Takihara, Y. et al.(員数10、6番目) Transcription of the Geminin gene is regulated by a negative-feedback loop. Mol. Biol. Cell 25, 1374-1383 (2014).
  • Yasunaga, S., Shirai, M., Takihara, Y. et al. (員数10、6番目) Scmh1 has E3 ubiquitin ligase activity for Geminin and histone H2A and regulates Geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4. Mol. Cell. Biol., 33:644-660 (2013).
  • Shirai, M., Takihara, Y., and Morisaki, T. Pcgf5 contributes to PRC1 (Polycomb repressive complex 1) in developing cardiac cells. The 7th TAKAO International Symposium on Ethology and Morphogenesis of Congenital Heart Disease. July 13-15, Tokyo (2013).
  • Hidaka, K., Shirai, M., Morisaki, T. et al. (員数9、4番目) Differentiation of pharyngeal endoderm from mouse embryonic stem cell. Stem cells Dev., 19, 1735-1743 (2010).
  • Hidaka, K., Shirai, M., Lee, J.-K., Wakayama, T., Kodama, I., Schneider, M. D., and Morisaki, T. The cellular prion protein identifies bipotential cardiomyogenic progenitors. Circ. Res., 106, 111-119 (2010).
  • Mizuta, E., Shirai, M., Morisaki, T. et al. (員数11、2番目) Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice. Biomedical research (Tokyo, Japan), 31(5), 301-305 (2010).
  • Jin, D., Hidaka, K., Shirai, M. and Morisaki, T. RNA-binding motif protein 24 regulates myogenin expression and promotes myogenic differentiation. Genes Cells 15, 1158-1167 (2010).
  • Shirai, M., Imanaka-Yoshida, K., Schneider, M. D., Schwartz, R. J. and Morisaki, T. T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. PNAS 106, 18604-18609 (2009).
  • Narumiya, H., Hidaka, K., Shirai, M., Terami, H., Aburatani, H. and Morisaki, T. Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling. Biochem Biophys Res Commun. 357, 896-902 (2007).
  • Terami, H., Hidaka, K., Shirai, M., Narumiya, H., Kuroyanagi. T., Arai, Y., Aburatani, H. and Morisaki, T. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Biochem Biophys Res Commun. 355(1), 47-53 (2007).
  • Kimura, E., Hidaka, K., Kid,a Y., Morisaki, H., Shirai, M., Araki, K., Suzuki, M., Yamamura, KI. and Morisaki, T. (2004). Serine-arginine-rich nuclear protein Luc7l regulates myogenesis inmice. Gene. 341, 41-47.
  • Sano, M., Shirai, M. (員数14, 3番目), Schneider, MD. Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure. EMBO J. 23, 3559-3569 (2004).
  • Brown, CO. 3rd, Chi, X., Garcia-Gras, E., Shirai, M., Feng, XH. and Schwartz, RJ. The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem. 279, 10659-10669 (2004).
  • Shirai, M., Osugi, T., Koga, H., Kaji, Y., Takimoto, E., Komuro, I., Hara, J., Miwa, T., Yamauchi-Takihara, K. & Takihara, Y. The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. J. Clin. Invest. 110, 177-184 (2002).
  • Koga, H., Kaji, Y., Nishii, K., Shirai, M., Tomotsune, D., Osugi, T., Sawada, A., Kim, J. Y., Hara, J., Miwa, T., Yamauchi-Takihara, K., Shibata, Y. & Takihara, Y. Overexpression of the Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in rae28-deficient mice, but causes dilated cardiomyopathy. Lab. Invest. 82 375-385 (2002).
  • Miwa T., Koyama T., Shirai M. Muscle specific expression of Cre recombinase under two actin promoters in transgenic mice. Genesis 26:136-138 (2000).
  • Takihara, Y., Tomotsune, D., Shirai, M., Katoh-Fukui, Y., Niishii, K., Motaleb, Md. A., Nomura, M., Tsuchiya, R., Fujita, Y., Shibata, Y., Higashinakagawa, T. & Shimada, K. Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development 124, 3673-3682 (1997).
受賞 第30回心筋生研究会Best Photograph賞(2008)
学位 博士(理学)
所属学会 日本分子生物学会、日本心臓血管発生研究会
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最終更新日 2016年12月01日

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