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Kazuki Sasaki

Name Kazuki Sasaki
Department Name,
Job Title
Laboratory Chief, Laboratory of Signal Regulation, Department of Molecular Pharmacology
Tel +81 6 6833 5004 ex. 2600
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Research Field Peptidomics
Research Result
  • Tsuchiya T, Osaki T, Minamino N, Sasaki K. Peptidomics for Studying Limited Proteolysis. J Proteome Res. 2015, 14: 4921-31.
  • Toshinai K, Saito T, Yamaguchi H, Sasaki K, Tsuchimochi W, Minamino N, Ueta Y, Nakazato M. Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus. Brain Res. 2014, 1563: 52-60.
  • Nonaka M, Kim R, Fukushima H, Sasaki K, Suzuki K, Okamura M, Ishii Y, Kawashima T, Kamijo S, Takemoto-Kimura S, Okuno H, Kida S, Bito H. Region-Specific Activation of CRTC1-CREB Signaling Mediates Long-Term Fear Memory. Neuron. 2014, 84: 92-106.
  • Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R. Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association. Cancer Res. 2014, 74: 3790-801
  • Sasaki K, Osaki T, Minamino N. Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry. Mol Cell Proteomics. 2013, 12:700-9.
  • Shimamura S, Sasaki K, Tanaka M. The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins. J Biol Chem. 2013, 288:1171-83.
  • Fujihara H, Sasaki K, Mishiro-Sato E, Ohbuchi T, Dayanithi G, Yamasaki M, Ueta Y, Minamino N. Molecular characterization and biological function of neuroendocrine regulatory peptide-3 in the rat. Endocrinology 2012, 153: 1377-86.
  • Osaki T, Sasaki K, Minamino N. Peptidomics-based discovery of an anti- microbial peptide derived from insulin-like growth factor-binding protein 5. J Proteome Res. 2011, 10:1870-80.
  • Yagi R, Tanaka M, Sasaki K, Kamata R, Nakanishi Y, Kanai Y, Sakai R. ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion. Oncogene. 2011, 30:1413-21.
  • Toshinai K, Yamaguchi H, Kageyama H, Matsuo T, Koshinaka K, Sasaki K, Shioda S, Minamino N, Nakazato M. Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus. Am J Physiol Endocrinol Metab. 2010, 299: E394-401.
  • Sasaki K, Takahashi N, Satoh M, Yamasaki M, Minamino N. A Peptidomics Strategy for discovering endogenous bioactive peptides. J Proteome Res. 2010, 9:5047-52.
  • Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, Minamino N. Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat. J Neurochem. 2010, 114:1097-106.
  • Tanaka M, Sasaki K, Kamata R, Hoshino Y, Yanagihara K, Sakai R. A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis. Mol Cell Biol. 2009, 29:402-13.
  • Sasaki K, Satomi Y, Takao T, Minamino N. Snapshot peptidomics of the regulated secretory pathway. Mol Cell Proteomics. 2009, 8:1638-47.
  • Tanaka M, Sasaki K, Kamata R, Sakai R. The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. J Cell Sci. 2007, 120:2179-89.
  • Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, González LJ, Shioda S, Takao T, Nakazato M, Minamino N. Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2. J Biol Chem. 2007, 282:26354-60.
  • Sasaki K, Sato K, Akiyama Y, Yanagihara K, Oka M, Yamaguchi K. Peptidomics-based approach reveals the secretion of the 29-residue COOH-terminal fragment of the putative tumor suppressor protein DMBT1 from pancreatic adenocarcinoma cell lines. Cancer Res. 2002, 62:4894-8.
  • Sato K, Sasaki K, Tsao MS, Yamaguchi K. Peptide differential display of serum-free conditioned medium from cancer cell lines. Cancer Lett. 2002, 176:199-203.
  • Sato K, Sasaki K, Akiyama Y, Yamaguchi K. Mass spectrometric high-throughput analysis of serum-free conditioned medium from cancer cell lines. Cancer Lett. 2001,170:153-9.
  • Nagasaki K, Sasaki K, Maass N, Tsukada T, Hanzawa H, Yamaguchi K. Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and tyrosine hydroxylase. Neurosci Lett. 1999, 267:177-80.
  • Nishimura E, Sasaki K, Maruyama K, Tsukada T, Yamaguchi K. Decrease in neuron-restrictive silencer factor (NRSF) mRNA levels during differentiation of cultured neuroblastoma cells. Neurosci Lett. 1996, 211:101-4.
  • Sasaki K, Tsukada T, Maruyama K, Yamaguchi K. Long-term regulation of synapsin I gene expression and neuronal morphology by cyclic AMP and low-dose staurosporine. Brain Res Mol Brain Res. 1996, 40:157-60.
  • Sasaki K, Tsukada T, Adachi I, Yamaguchi K. Staurosporine potentiates cAMP-mediated promoter activity of the vasoactive intestinal polypeptide gene in rat pheochromocytoma PC12 cells. Biochem Biophys Res Commun. 1995, 214:1114-20.
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