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Department of Molecular Innovation in Lipidology

Members

Director Mariko Harada-Shiba
Laboratory chiefs Masatsune Ogura, Mika Hori
Research Fellow Fumito Wada, Ryu Niinaga
Trainees Motoki Sawamura, Reiko Waki, Yukiko Hasegawam, Masahito Michikura, Chizuru Fuke, Shunsuke Wada, Tetsuya Ueda
Secretary Akiko Yoshida

Summary of Research Activity in Department of Molecular Innovation in Lipidology

Dyslipidemia is one of the major factors that may cause cardiovascular disease. We have reported that familial hypercholesterolemia shows premature atherosclerosis, causing angina pectoris or myocardial infarction (under collaboration with Division of Endocrinology and Metabolism and Division of Preventive Cardiology). LDL receptor, PCSK9 and LDLRAP1 genes that are known to cause familial hypercholesterolemia (FH) are analyzed for clinical diagnosis and treatment (under collaboration with Testing Division).

We are involved in making the guideline for familial hypercholesterolemia based on the multi-center trial. In order to clarify the molecular mechanism of dyslipidemia causing cardiovascular disease, model animals of dyslipidemia are analyzed for involvement of molecules in establishment of atherosclerosis. We are further developing a new therapeutic approach for treatment of dyslipidemia using antisense and siRNA nucleic acid drugs (under collaboration with Dr. Obika of Osaka University), as well as that of pulmonary arterial hypertension using a non-viral gene delivery method (under collaboration with Dr. Kataoka of Tokyo University).

Major Research Subjects

  1. Clinical analysis of familial hypercholesterolemia and establishing its guideline
  2. Molecular analysis of genes related to pathogenesis and pathophysiology of cardiovascular disease
  3. Development of novel therapeutic approach using nucleic acid drug for treatment of cardiovascular disease
  4. Development of novel therapeutic approach using gene delivery method for treatment of cardiovascular disease
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