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Hirotsugu Tsuchimochi

Name Hirotsugu Tsuchimochi, Ph.D. Hirotsugu Tsuchimochi, Ph.D.
Department Name,
Job Title
Laboratory Chief of Integrative Physiology, Department of Cardiac Physiology
Tel +81-6-6833-5004 (ext. 2381)
Fax +81-6-6835-5416
E-Mail tsuchimo@ncvc.go.jp
Research Field Exercise and Cardiovascular Physiology, Autonomic nervous system physiology
Research Result
  • Shirai M, Tsuchimochi H, Nagai H, Gray E, Pearson JT, Sonobe T, Yoshimoto M, Inagaki T, Fujii Y, Umetani K, Kuwahira I, Schwenke DO. Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia. Basic Res Cardiol. 109: 432, 2014.
  • Yamauchi K, Tsuchimochi H, Stone AJ, Stocker SD, Kaufman MP. Increased dietary salt intake enhances the exercise pressor reflex. Am J Physiol Heart Circ Physiol. 306: H450-H454, 2014.
  • Pearson JT, Jenkins MJ, Edgley AJ, Sonobe T, Joshi M, Waddingham MT, Fujii Y, Schwenke DO, Tsuchimochi H, Yoshimoto M, Umetani K, Kelly DJ, Shirai M. Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation. Cardiovasc Diabetol. 12: 111, 2013.
  • Gray EA, Tsuchimochi H, Pearson JT, Sonobe T, Fujii Y, Yoshimoto M, Umetani K, Shirai M, Schwenke DO. Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension. J Synchrotron Radiat. 20: 756-764, 2013.
  • Endo K, Matsukawa K, Liang N, Nakatsuka C, Tsuchimochi H, Okamura H, Hamaoka T. Dynamic exercise improves cognitive function in association with increased prefrontal oxygenation. J Physiol Sci. 63: 287-298, 2013.
  • Shirai M, Beard M, Pearson JT, Sonobe T, Tsuchimochi H, Fujii Y, Gray E, Umetani K, Schwenke DO. Impaired pulmonary blood flow distribution in congestive heart failure assessed using synchrotron radiation microangiography. J Synchrotron Radiat. 20: 441-448, 2013.
  • Shirai M, Schwenke DO, Tsuchimochi H, Umetani K, Yagi N, Pearson JT. Synchrotron radiation imaging for advancing our understanding of cardiovascular function. Circ Res. 112: 209-221, 2013.
  • Murata J, Matsukawa K, Komine H, and Tsuchimochi H. Modulation of radial blood flow during Braille character discrimination task. Acta physiologica Hungarica, 99: 25-32, 2012.
  • Tsuchimochi H, Yamauchi K, McCord JL, and Kaufman MP. Blockade of acid sensing ion channels attenuates the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. The Journal of Physiology, 589: 6173-6189, 2011.
  • Leal AK, McCord JL, Tsuchimochi H, and Kaufman MP. Blockade of the TP receptor attenuates the exercise pressor reflex in decerebrated rats with chronic femoral artery occlusion. American Journal of Physiology-Heart and Circulatory Physiology, 301 (5): H2140-2146, 2011.
  • McCord JL, Tsuchimochi H, Yamauchi K, Leal AK, and Kaufman MP. Tempol attenuates the exercise pressor reflex independently of neutralizing reactive oxygen species in femoral arterial ligated rats. Journal of Applied Physiology, 111: 971-979, 2011.
  • Tsuchimochi H, McCord JL, Leal AK, and Kaufman MP. Dorsal root tetrodotoxin-resistant sodium channels do not contribute to the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. American Journal of Physiology-Heart and Circulatory Physiology 300 (2): H652-663, 2011.
  • McCord JL, Tsuchimochi H and Kaufman MP. P2X2/3 and P2X3 receptors contribute to the metaboreceptor component of the exercise pressor reflex in decerebrated cats. Journal of Applied Physiology 109 (5): 1416-1423, 2010.
  • Tsuchimochi H, McCord JL and Kaufman MP. Peripheral µ-opioid receptors attenuate the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. American Journal of Physiology-Heart and Circulatory Physiology 299 (2): H557-565, 2010.
  • Tsuchimochi H, McCord JL and Kaufman MP. Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats. American Journal of Physiology-Heart and Circulatory Physiology 299 (1): H106-113, 2010.
  • Tsuchimochi H, Nakamoto T and Matsukawa K. Centrally evoked increase in adrenal sympathetic outflow elicits immediate secretion of adrenaline in anaesthetized rats. Experimental Physiology 95: 93-106, 2010.
  • McCord JL, Tsuchimochi H and Kaufman MP. Acid-sensing ion channels contribute to the metaboreceptor component of the exercise pressor reflex. American Journal of Physiology-Heart and Circulatory Physiology 297: H443-H449, 2009.
  • Tsuchimochi H, Hayes SG, McCord JL and Kaufman MP. Both central command and exercise pressor reflex activate cardiac sympathetic nerve activity in decerebrate cats. American Journal of Physiology-Heart and Circulatory Physiology 296: H1157-H1163, 2009.
  • Tsuchimochi H, Matsukawa K, Komine H and Murata J. Direct measurement of cardiac sympathetic efferent nerve activity during dynamic exercise. American Journal of Physiology-Heart and Circulatory Physiology 283: H1896-H1906, 2002.
  • Tsuchimochi H, Inashima S, and Wada M. Effect of dithiothreitol on Ca2+-ATPase activity of sarcoplasmic reticulum in rat skeletal muscle after high-intensity exercise. Japanese Journal of Physical Fitness and Sports Medicine 50: 325-332, 2001 (Article in Japanese).
  • Wada M, and Tsuchimochi H. Dysfunction of Sarcoplasmic Reticulum by Exercise. Japanese Journal of SPORTS SCIENCES 15: 279-285, 1996 (Article in Japanese).
Academic Award Received
Academic Degree Doctor of Philosophy in Health Sciences
Academic Society Affiliation
  • American Physiological Society
  • Physiological Society of Japan
  • Japanese Society of Physical Fitness and Sports Medicine
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