Until the opening of the National Cardiovascular Center
| January, 1966 | Cardiovascular Disease Research Liaison Committee in the 7th Division of the Science Council of Japan submitted a request to the Ministry of Health and Welfare for the establishment of a cardiovascular center. |
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| October, 1966 | The Japanese Circulation Society submitted a written request for the establishment of the National Cardiovascular Center to the Science Council of Japan. The Science Council of Japan accepted it and decided to with the Ministry of Health and Welfare for the establishment of the Center. |
| August, 1968 to March, 1969 | Preliminary meetings were held three times to evaluate the possibility of the project. |
| July, 1969 to March, 1970 | To deliberate basic planning, the preliminary committee and subcommittee in charge of organization, equipment and architecture were organized, and meetings were held seven times. |
| December, 1971 | Consultation and fundamental agreement were effected with the Governor of Osaka Prefecture to lease the prefecture-owned land ( in Senri New Town). |
| July, 1972 | Basic plan for the construction of the National Cardiovascular Center was made. |
| December, 1972 | In the National Hospital Division of the Medical Affairs Bureau of the Ministry of Health and Welfare, a section was organized for the preparation of the establishment of the National Cardiovascular Center. |
| December, 1972 to June, 1973 | The Committee for the establishment of the National Cardiovascular Center held meetings three times to discuss the basic plan. |
| June, 1973 | The design for the construction of hospital and administrative section was completed. |
| July, 1973 | The final committee for the establishment of the National Cardiovascular Center was organized and detailed planning was discussed by the Hospital Special Committee and Institute Special Committee. |
| December, 1973 | A contract was signed with the Governor of Osaka Prefecture for the land to be used. |
| March, 1974 | Construction of the hospital and administrative building started. |
| April, 1976 | A section for the preparation of the opening of the National Cardiovascular Center was organized. |
| March, 1977 | Construction of Research Institute started. |
| May, 1977 | Construction of the Hospital and annex for administrative section was completed. The Ministry of Health and Welfare Establishment law was partially revised for the establishment of the Center. |
| June, 1977 | Appointments of the president, Dr. Tsuneo Yosida, and other staff personnels were promulgated. |
| July, 1977 | The inauguration ceremony of the center was held in the presence of Prince and Princess Hitachinomiya. |
The first 10 years
| August,1977 | The Hospital and the Research Institute went into action. Three general wards and Intensive Care Unit (ICU) opened. |
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| September, 1977 | The prime minister Fukuda inspected the Center. |
| October, 1977 | Coronary Care Unit (CCU) opened. |
| April, 1978 | Residency system began. |
| May, 1978 | Six general wards and special wards (infants'ward, SCU) opened. |
| February, 1979 | Construction of the Research Institute started. Medical cooperation with People's Republic of Bangladesh began as Cardiovascular Diseases Control Project in the People's Republic of Bangladesh. |
| May, 1979 | Additional two general wards and a special ward (NCU) opened. |
| February, 1980 | Construction of the library started. |
| April, 1980 | A general ward opened. |
| March, 1981 | Construction of the library was completed. |
| January, 1982 | A special ward of prenatal care opened. |
| August, 1983 | The first president, Dr. Tsuneo Yosida, resigned. Dr. Hisao Manabe was installed as the second president. |
| November, 1983 | Director-General of WHO, Dr. Mahler, inspected the Center. |
| October, 1984 | The Department of Structural Analysis was established in the Research Institute. |
| February, 1986 | The National Cardiovascular Center was designated as a WHO Collaborating Center. |
| June, 1986 | Construction of the annex to the Research Institute was completed. |
| May, 1987 | Division of Pharmacy was established in the Hospital. |
| June, 1987 | Installation of constant voltage and constant frequency equipment was completed. |
| October, 1987 | The Department of Bioscience was established in the Research Institute. |
| November, 1987 | The 10th anniversary was celebrated. |
The next 10 years
| March, 1988 | Construction of radioisotope ward started. |
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| December, 1989 | Construction of rehabilitation ward started. |
| March, 1990 | Construction of radioisotope ward was completed. The second president, Dr. Hisao Manabe, resigned. |
| April, 1990 | Dr. Teruo Omae was installed as the third president. |
| March, 1992 | Construction of rehabilitation ward was completed. |
| September, 1993 | The National Cardiovascular Center was approved as a specially functioned hospital. |
| March, 1995 | The third president, Dr. Teruo Omae, resigned. |
| April, 1995 | Dr. Yasuo Kawashima was installed as the fourth president. |
| March, 1996 | The system of JUN Net was established. |
| September, 1996 | The fourth president, Dr. Yasuo Kawashima, resigned. |
| October, 1996 | Dr. Haruhiko Kikuchi was installed as the fifth president. |
| October, 1997 | The heart transplant countermeasure room was established. |
| November, 1997 | The center foundation the 20th anniversary commemoration ceremony. |
| July, 1998 | The internal organs offer countermeasure room was established. |
| October, 1998 | The practical use start of G7 image reference center. |
| March, 1999 | The division of clinical trial management was established. |
| March, 2000 | Construction of biotechnology ward was completed. |
| June, 2000 | The fifth president, Dr. Haruhiko Kikuchi, resigned. |
| July, 2000 | Dr. Takenori Yamaguchi was installed as the sixth president. |
| March, 2001 | The sixth president, Dr. Takenori Yamaguchi, resigned. |
| April, 2001 | Dr. Soichiro Kitamura was installed as the seventh president. |
| March, 2008 | The seventh president, Dr. Soichiro Kitamura, resigned. |
| April, 2008 | Dr. Nobuo Hashimoto was installed as the eighth president. |
After an independent administrative agency shift.
| April, 2010 | Shifted to the independent administrative agency. |
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| The first chief director Nobuo Hashimoto assumption of office. | |
| Research and development base center establishment. | |
| June, 2010 | Hospital usability test authorization by Japan Council for Quality Health Care Foundation. |
